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WNT Signaling

The WNT pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when WNT proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe WNT signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical WNT signaling involves binding of WNT proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical WNT pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the WNT/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. WNT proteins play important roles in the normal physiology of adult tissues and aberrant WNT signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.[1]

1.Logan CY and Nusse R. 2004. The WNT signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

 

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    SFRP1 Antibody (OASA08759)

    SFRP1 Antibody (OASA08759)

    Protein Name:Secreted frizzled-related protein 1
    Catalog #:OASA08759
    Type: pAb
    Reacts with: Human
    Application: ELISA, IHC-FFPE, WB
    Product Size: 50 ug
    Price (USD): $709.00
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    CACYBP antibody - middle region (ARP51259_T100) in Human HepG2 using Western Blot

    CACYBP Antibody - middle region (ARP51259_T100)

    Protein Name:Calcyclin-binding protein
    Catalog #:ARP51259_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    MYC Antibody (OASA00538) in c-myc tagged protein using ELISA

    MYC Antibody (OASA00538)

    Protein Name:Myc proto-oncogene protein
    Catalog #:OASA00538
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, ELISA, FC, IHC-FFPE, WB
    Product Size: 1 mg
    Price (USD): $809.00
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    Gsk3b Antibody (OASA07320)

    Gsk3b Antibody (OASA07320)

    Protein Name:Glycogen synthase kinase-3 beta
    Catalog #:OASA07320
    Type: pAb
    Reacts with: Rat
    Application: WB
    Product Size: 0.1 ml
    Price (USD): $770.00
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    SMAD3 Antibody (OASA08793)

    SMAD3 Antibody (OASA08793)

    Protein Name:Mothers against decapentaplegic homolog 3
    Catalog #:OASA08793
    Type: pAb
    Reacts with: Human
    Application: ELISA, IHC-FFPE, WB
    Product Size: 50 ug
    Price (USD): $770.00
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    CCND1 Antibody (OASA00562)

    CCND1 Antibody (OASA00562)

    Protein Name:G1/S-specific cyclin-D1
    Catalog #:OASA00562
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, ELISA, FC, IP, IHC-FFPE, WB
    Product Size: 0.1 mg
    Price (USD): $565.00
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    MAP3K7 Antibody (OASA06465)

    MAP3K7 Antibody (OASA06465)

    Protein Name:Mitogen-activated protein kinase kinase kinase 7
    Catalog #:OASA06465
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $545.00
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    RBX1 antibody - middle region (AVARP03042_T100) in Human HepG2 using Western Blot

    RBX1 Antibody - middle region (AVARP03042_T100)

    Protein Name:
    Catalog #:AVARP03042_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    Camk2a Antibody (OASA07105)

    Camk2a Antibody (OASA07105)

    Protein Name:Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Catalog #:OASA07105
    Type: pAb
    Reacts with: Human
    Application: ELISA, IF, IHC-FFPE, WB
    Product Size: 50ug
    Price (USD): $695.00
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    CSNK1A1L antibody - middle region (ARP52809_P050) in Human 721_B using Western Blot

    CSNK1A1L Antibody - middle region (ARP52809_P050)

    Protein Name:Casein kinase I isoform alpha-like
    Catalog #:ARP52809_P050
    Type: pAb
    Reacts with: Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    PRKCA Antibody (OASA03762)

    PRKCA Antibody (OASA03762)

    Protein Name:Protein kinase C alpha type
    Catalog #:OASA03762
    Type: mAb
    Reacts with:
    Application: IHC-AFF, WB
    Product Size: 2 ml
    Price (USD): $509.00
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    WNT4 Antibody (OASA06495) in Human ovary and human testis using Western Blot

    WNT4 Antibody (OASA06495)

    Protein Name:Protein Wnt-4
    Catalog #:OASA06495
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $545.00

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