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Now Offering Over 102,157 Antibodies & 44,722 Antigens!

WNT Signaling

The Wnt pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when Wnt proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe Wnt signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical Wnt signaling involves binding of Wnt proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical Wnt pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the Wnt/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. Wnt proteins play important roles in the normal physiology of adult tissues and aberrant Wnt signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.[1]

1.Logan CY and Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

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Wnt signaling pathway image by Aviva Systems Biology

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    JUN antibody - N-terminal region (P100911_P050) in Human HEK293T using Western Blot

    JUN antibody - N-terminal region (P100911_P050)

    Protein Name:Transcription factor AP-1
    Catalog #:P100911_P050
    Type: pAb
    Reacts with: Cow, Dog, Human, Mouse, Pig, Rabbit, Rat, Sheep
    Application: CHIP, IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
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    NKD1 antibody - N-terminal region (ARP41285_P050) in Human HepG2 using Western Blot

    NKD1 antibody - N-terminal region (ARP41285_P050)

    Protein Name:Protein naked cuticle homolog 1
    Catalog #:ARP41285_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $289.00
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    MMP7 Antibody (OASA06351)

    MMP7 Antibody (OASA06351)

    Protein Name:Matrilysin
    Catalog #:OASA06351
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $545.00
  •  
    Camk2a Antibody (OASA07105)

    Camk2a Antibody (OASA07105)

    Protein Name:Calcium/calmodulin-dependent protein kinase type II subunit alpha
    Catalog #:OASA07105
    Type: pAb
    Reacts with: Human
    Application: ELISA, IF, IHC-FFPE, WB
    Product Size: 50ug
    Price (USD): $695.00
  •  
    TP53 Antibody (OASA03187)

    TP53 Antibody (OASA03187)

    Protein Name:Cellular tumor antigen p53
    Catalog #:OASA03187
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, IP, IHC-FFPE, WB
    Product Size: 0.1mg
    Price (USD): $410.00
  •  
    DKK1 Antibody (OASA07692)

    DKK1 Antibody (OASA07692)

    Protein Name:Dickkopf-related protein 1
    Catalog #:OASA07692
    Type: pAb
    Reacts with: Human
    Application: IHC-FFPE
    Product Size: 50ug
    Price (USD): $770.00
  •  
    CSNK2A1 Antibody (OASA07503)

    CSNK2A1 Antibody (OASA07503)

    Protein Name:Casein kinase II subunit alpha
    Catalog #:OASA07503
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 50ug
    Price (USD): $425.00
  •  
    PRKCA Antibody (OASA03762)

    PRKCA Antibody (OASA03762)

    Protein Name:Protein kinase C alpha type
    Catalog #:OASA03762
    Type: mAb
    Reacts with:
    Application: IHC-AFF, WB
    Product Size: 2ml
    Price (USD): $410.00
  •  
    CCND2 Antibody (OASA00564)

    CCND2 Antibody (OASA00564)

    Protein Name:G1/S-specific cyclin-D2
    Catalog #:OASA00564
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, IP, WB
    Product Size: 0.1mg
    Price (USD): $735.00
  •  
    PPP2R5D Antibody (OASA06402)

    PPP2R5D Antibody (OASA06402)

    Protein Name:Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
    Catalog #:OASA06402
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $545.00
  •  
    SIAH1 Antibody (OASA06445)

    SIAH1 Antibody (OASA06445)

    Protein Name:E3 ubiquitin-protein ligase SIAH1
    Catalog #:OASA06445
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $545.00
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    EP300 Antibody (OASA08061)

    EP300 Antibody (OASA08061)

    Protein Name:Histone acetyltransferase p300
    Catalog #:OASA08061
    Type: pAb
    Reacts with: Human
    Application: IP, WB
    Product Size: 0.1mg
    Price (USD): $640.00
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    PKA CATALYTIC SUBUNIT Antibody (OASA00361)

    PKA CATALYTIC SUBUNIT Antibody (OASA00361)

    Protein Name:cAMP-dependent protein kinase catalytic subunit alpha
    Catalog #:OASA00361
    Type: mAb
    Reacts with:
    Application: ELISA
    Product Size: 0.2mg
    Price (USD): $360.00
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    RAC2 Antibody (OASA06415)

    RAC2 Antibody (OASA06415)

    Protein Name:Ras-related C3 botulinum toxin substrate 2
    Catalog #:OASA06415
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $575.00
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    CTNNB1 Antibody (OASA07131)

    CTNNB1 Antibody (OASA07131)

    Protein Name:Catenin beta-1
    Catalog #:OASA07131
    Type: pAb
    Reacts with: Human
    Application: IHC-AFF, ELISA, WB, IP, IHC-FFPE
    Product Size: 50ul
    Price (USD): $860.00

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