WNT Signaling

The WNT pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when WNT proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe WNT signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical WNT signaling involves binding of WNT proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical WNT pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the WNT/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. WNT proteins play important roles in the normal physiology of adult tissues and aberrant WNT signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.[1]

1.Logan CY and Nusse R. 2004. The WNT signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

 

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  1. Human Jurkat
    TBL1XR1 Antibody - C-terminal region (ARP61921_P050)
    Catalog #: ARP61921_P050
    Protein Name: F-box-like/WD repeat-containing protein TBL1XR1
    Alias: C21, DC42, FLJ12894, IRA1, TBLR1
    Tested Species: Human
    Predicted Species: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  2. Mouse Heart
    Ppp3cb Antibody - C-terminal region (ARP57516_P050)
    Catalog #: ARP57516_P050
    Protein Name: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
    Alias: 1110063J16Rik, Calnb, CnAbeta, Cnab
    Tested Species: Mouse
    Predicted Species: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  3. WNT2B Antibody (OASA08917)
    WNT2B Antibody (OASA08917)
    Catalog #: OASA08917
    Protein Name: Protein Wnt-2b
    Alias: WNT13, XWNT2, WNT2B
    Predicted Species: Human
    Application: IHC-FFPE
    Format: Purified IgG - liquid
    Size: 50 ug
    Price:
    $709.00
  4. SMAD3 Antibody (OASA08793)
    SMAD3 Antibody (OASA08793)
    Catalog #: OASA08793
    Protein Name: Mothers against decapentaplegic homolog 3
    Alias: MADH3, JV15-2, HSPC193, HsT17436, MGC60396, DKFZp586N0721, DKFZp686J10186, SMAD3
    Predicted Species: Human
    Application: IHC-FFPE, WB
    Format: Purified IgG - liquid
    Size: 50 ug
    Price:
    $709.00
  5. SFRP1 Antibody (OASA08759)
    SFRP1 Antibody (OASA08759)
    Catalog #: OASA08759
    Protein Name: Secreted frizzled-related protein 1
    Alias: FRP, FRP1, FrzA, FRP-1, SARP2, SFRP1
    Predicted Species: Human
    Application: IHC-FFPE, WB
    Format: Purified IgG - liquid
    Size: 50 ug
    Price:
    $829.00
  6. WNT1 Antibody (OASA08277)
    WNT1 Antibody (OASA08277)
    Catalog #: OASA08277
    Protein Name: Proto-oncogene Wnt-1
    Alias: INT1, WNT1
    Predicted Species: Human
    Application: WB
    Format: Purified IgG - lyophilised
    Size: 0.1 mg
    Price:
    $709.00
  7. DKK1 Antibody (OASA07692)
    DKK1 Antibody (OASA07692)
    Catalog #: OASA07692
    Protein Name: Dickkopf-related protein 1
    Alias: SK, DKK-1, DKK1
    Predicted Species: Human
    Application: IHC-FFPE
    Format: Purified IgG - liquid
    Size: 50 ug
    Price:
    $709.00
  8. FZD7 Antibody - C-terminal region (OASA07260)
    FZD7 Antibody - C-terminal region (OASA07260)
    Catalog #: OASA07260
    Protein Name: Frizzled-7
    Alias: FzE3, FZD7
    Predicted Species: Human
    Application: IHC-FFPE
    Format: Purified IgG - liquid
    Size: 50 ug
    Price:
    $829.00
  9. MMP7 Antibody (OASA06351)
    MMP7 Antibody (OASA06351)
    Catalog #: OASA06351
    Protein Name: Matrilysin
    Alias: MMP-7, MPSL1, PUMP-1, MMP7
    Predicted Species: Human
    Application: WB
    Format: Purified IgG - liquid
    Size: 0.1 mg
    Price:
    $709.00
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