While Coronaviruses have been causing typical colds in humans for most of history, the recent emergence of SARS-CoV-2 and the resulting disease COVID-19 has inspired the research community to attack this pandemic with research on mechanisms of spread, infectivity, and viral mechanisms contributing to the pleiotropic effects of the disease. Aviva Systems Biology offers antibodies and recombinant proteins that may be useful for understanding the interactions of virus derived proteins that interact with host proteins, such as the Spike S1 interaction with the host ACE2 receptor. Antibodies and antibody pairs are useful for detection of viral proteins, and the recombinant Spike S1/RBD variants can be used as interaction probes to explore the consequence of viral mutation on the important host:protein interactions.

SARS-CoV-2 Antibody and Recombinant Protein Research Products

Targets: "S" Surface Glycoprotein | "N" Nucleocapsid | "E" Envelope Protein | ORF1a Polyprotein | ACE2

"S" Surface Glycoprotein

The spike glycoprotein is found on the outside of the virus particle and gives coronavirus viruses their crown-like appearance. This glycoprotein mediates attachment of the virus particle and entry into the host cell. S protein is an important target for vaccine development, antibody therapies and diagnostic antigen-based tests. (Source NCBI)

"S" Surface Glycoprotein Antibodies

Catalog NumberProduct NameType
OAPB00314SARS-CoV-2 Spike Antibody (OAPB00314)Polyclonal Antibody
OAAQ00225SARS-CoV-2 Spike S1 (C-A11) Neutralizing Antibody (OAAQ00225)Monoclonal Antibody
OAAN06661SARS-CoV-2 Spike Antibody (OAAN06661)Monoclonal Antibody
OAAV00484COVID-19 & SARS-CoV S glycoprotein Antibody (OAAV00484)Monoclonal Antibody
OAAV00485COVID-19 & SARS-CoV S glycoprotein Antibody (OAAV00485) Monoclonal Antibody

"S" Surface Glycoprotein Recombinant Proteins

Catalog NumberProduct NameType
OPSN00002SARS-CoV-2 Spike Receptor Binding Domain Recombinant Protein (OPSN00002)Recombinant Protein
OPSN00004SARS-CoV-2 Spike Receptor Binding Domain  N501Y (UK Variant Alpha) Recombinant Protein (OPSN00004)Recombinant Protein
OPSN00006SARS-CoV-2 Spike Receptor Binding Domain  E484K, N501Y (South Africa Variant Beta) Recombinant Protein (OPSN00006)Recombinant Protein
OPSN00008Human ACE2 Recombinant Protein (OPSN00008)Recombinant Protein
OPSN00009SARS-CoV-2 Spike Receptor Binding Domain L452R, E484Q (India Variant) Recombinant Protein (OPSN00010)Recombinant Protein
OPSN00011SARS-CoV-2 Spike Receptor Binding DomainL452R, T478K (India Variant Delta) Recombinant Protein (OPSN00011)Recombinant Protein
OOEF01080Recombinant Coronavirus (COVID-19) (SARS-CoV-2) Spike Protein RBD Antigen (OOEF01080)Recombinant Protein
OOEF01081Recombinant Coronavirus (COVID-19) (SARS-CoV-2) Spike Protein S1 Antigen (OOEF01081)Recombinant Protein
OOEF01084Recombinant Coronavirus (COVID-19) (SARS-CoV-2) Spike Protein RBD Antigen (OOEF01084)Recombinant Protein
OOEF01085Recombinant Coronavirus (COVID-19) (SARS-CoV-2) Spike Protein S1 Antigen (OOEF01085)Recombinant Protein
OPAN06662Recombinant SARS-CoV-2 Spike RBD Protein (OPAN06662)Recombinant Protein
OPAN06663Recombinant SARS-CoV-2 Spike S1 Protein (OPAN06663)Recombinant Protein
OPAN06664Recombinant SARS-CoV-2 S1+S2 ECD (S-ECD) Protein (OPAN06664)Recombinant Protein
OPAN06665Recombinant SARS-CoV-2 Spike S1 Protein (OPAN06665)Recombinant Protein
OPAN06666Recombinant SARS-CoV-2 Spike S1 Protein (OPAN06666)Recombinant Protein
OPAR00001Recombinant SARS-CoV-2 Spike Protein (OPAR00001)Recombinant Protein
OPCA335978Recombinant SARS-CoV-2 Spike Glycoprotein (OPCA335978)Recombinant Protein
OPCA335979Recombinant SARS-CoV-2 Spike Glycoprotein (OPCA335979)Recombinant Protein
OPCA335982Recombinant SARS-CoV-2 Spike Glycoprotein (OPCA335982)Recombinant Protein
OPCA335983Recombinant SARS-CoV-2 Spike Glycoprotein (OPCA335983)Recombinant Protein
OPCA335986Recombinant SARS-CoV-2 Spike Glycoprotein (OPCA335986)Recombinant Protein
OPCA335987Recombinant SARS-CoV-2 Spike Glycoprotein (OPCA335987)Recombinant Protein
OPEF01788Recombinant Coronavirus (COVID-19) (SARS-CoV-2) S1 Antigen (OPEF01788)Recombinant Protein
OPEF01789Recombinant Coronavirus (COVID-19) (SARS-CoV-2) S2 Antigen (OPEF01789)Recombinant Protein
OPFA00006Recombinant SARS-COV-2 Spike Protein (OPFA00006)Recombinant Protein
OPFA00007Recombinant SARS-COV-2 Spike Protein (OPFA00007)Recombinant Protein
OPMA04850SARS-CoV-2 Spike S1 RBD Recombinant Protein (OPMA04850)Recombinant Protein
OPMA04851SARS-CoV-2 Spike S1 Recombinant Protein (OPMA04851)Recombinant Protein
OPMA04852SARS-CoV-2 Nucleocapsid Recombinant Protein (OPMA04852)Recombinant Protein
OPMA04854SARS-CoV-2 Spike S1 (NTD) Recombinant Protein (OPMA04854)Recombinant Protein
OPMA04855SARS-CoV-2 Spike S1 RBD Recombinant Protein (OPMA04855)Recombinant Protein
OPMA04856SARS-CoV-2 Spike S2 Recombinant Protein (OPMA04856)Recombinant Protein
OPMA04853SARS-CoV-2 Spike S1 Recombinant Protein (OPMA04853)Recombinant Protein

"N" Nucleocapsid Phosphoprotein

The nucleocapsid phosphoprotein is a structural protein that binds to, protects the viral RNA genome and is involved in packaging the RNA into virus particles. The N protein has been suggested as an antiviral drug target. (Source NCBI)

"N" Nucleocapsid Antibodies

Catalog NumberProduct NameType
OAAQ00211SARS-CoV-2 Nucleoprotein (N) (75G5a) Paired Antibody (OAAQ00211)Monoclonal Antibody
OAAQ00212SARS-CoV-2 Nucleoprotein (N) (84C4a) Paired Antibody (OAAQ00212)Monoclonal Antibody
OAAQ00213SARS-CoV-2 Nucleoprotein (N) (84D7) Paired Antibody (OAAQ00213)Monoclonal Antibody
OAAQ00214SARS-CoV-2 Nucleoprotein (N) (85C1) Paired Antibody (OAAQ00214)Monoclonal Antibody
OAAQ00215SARS-CoV-2 Nucleoprotein (N) (75G5a) Paired Antibody-Biotin (OAAQ00215)Monoclonal Antibody
OAAQ00216SARS-CoV-2 Nucleoprotein (N) (84C4a) Paired Antibody-Biotin (OAAQ00216)Monoclonal Antibody
OAAQ00217SARS-CoV-2 Nucleoprotein (N) (84D7) Paired Antibody-Biotin (OAAQ00217)Monoclonal Antibody
OAAQ00218SARS-CoV-2 Nucleoprotein (N) (85C1) Paired Antibody-Biotin (OAAQ00218)Monoclonal Antibody
OAAQ00219SARS-CoV-2 Nucleoprotein (N) (85C10) Paired Antibody (OAAQ00219)Monoclonal Antibody
OAAQ00220SARS-CoV-2 Nucleoprotein (N) (85C10) Paired Antibody-Biotin (OAAQ00220)Monoclonal Antibody
OAAQ00221SARS-CoV-2 Nucleoprotein (N) (85B4) Paired Antibody (OAAQ00221)Monoclonal Antibody
OAAQ00222SARS-CoV-2 Nucleoprotein (N) (85B4) Paired Antibody-Biotin (OAAQ00222)Monoclonal Antibody
OAAQ00223SARS-CoV-2 Nucleoprotein (N) (85E9) Paired Antibody (OAAQ00223)Monoclonal Antibody
OAAQ00224SARS-CoV-2 Nucleoprotein (N) (85E9) Paired Antibody-Biotin (OAAQ00224)Monoclonal Antibody
OAAN06660SARS-CoV-2 Nucleoprotein Antibody (OAAN06660)Monoclonal Antibody
OAAV00486Covid-19 & SARS-CoV Nucleoprotein Antibody (OAAV00486)Monoclonal Antibody
OAAV00487Covid-19 & SARS-CoV Nucleoprotein Antibody (OAAV00487)Monoclonal Antibody
OAAV00488Covid-19 & SARS-CoV Nucleoprotein Antibody (OAAV00488)Monoclonal Antibody
OAAV00489Covid-19 & SARS-CoV Nucleoprotein Antibody (OAAV00489)Monoclonal Antibody
OAFA00001SARS-COV-2 Nucleoprotein Antibody (OAFA00001)Monoclonal Antibody
OAFA00002SARS-COV-2 Nucleoprotein Antibody (OAFA00002)Monoclonal Antibody
OAFA00003SARS-COV-2 Nucleoprotein Antibody (OAFA00003)Monoclonal Antibody
OAFA00004SARS-COV-2 Nucleoprotein Antibody (OAFA00004)Monoclonal Antibody
OAFA00005SARS-COV-2 Nucleoprotein Antibody (OAFA00005)Monoclonal Antibody
OAMA04858SARS-CoV-2 Nucleocapsid Antibody (OAMA04858)Monoclonal Antibody
OAMA04859SARS-CoV-2 Nucleocapsid Antibody (OAMA04859)Monoclonal Antibody

"N" Nucleocapsid Recombinant Proteins

Catalog NumberProduct NameType
OPAQ00226SARS-CoV-2 Nucleoprotein Recombinant Protein (ELISA Control) (OPAQ00226)Recombinant Protein
OOEF01086Recombinant Coronavirus (COVID-19) (SARS-CoV-2 NP) Antigen (OOEF01086)Recombinant Protein
OOEF01087Recombinant Coronavirus (COVID-19) (SARS-CoV-2 NP) Antigen (OOEF01087)Recombinant Protein
OOEF01088Recombinant Coronavirus (COVID-19) (SARS-CoV-2 NP) Antigen (OOEF01088)Recombinant Protein
OOEF01089Recombinant Coronavirus (COVID-19) (SARS-CoV-2) NP Antigen (OOEF01089)Recombinant Protein
OPCA335980Recombinant SARS-CoV-2 Nucleoprotein (OPCA335980)Recombinant Protein
OPCA335981Recombinant SARS-CoV-2 Nucleoprotein (OPCA335981)Recombinant Protein
OPCA335984Recombinant SARS-CoV-2 Nucleoprotein (OPCA335984)Recombinant Protein
OPCA335988Recombinant SARS-CoV-2 Nucleoprotein (OPCA335988)Recombinant Protein
OPCA335989Recombinant SARS-CoV-2 Nucleoprotein (OPCA335989)Recombinant Protein
OPEF01790Recombinant Coronavirus (COVID-19) (SARS-CoV-2) NP Antigen (OPEF01790)Recombinant Protein
OPMA04857SARS-CoV-2 Nucleocapsid Recombinant Protein (OPMA04857)Recombinant Protein

"E" Envelope Protein

The envelope protein is found in virus particles. This protein facilitates assembly and release of the virus and has ion channel activity required for pathogenesis. (Source NCBI)

Catalog NumberProduct NameType
OAPB00317SARS-CoV-2 Envelope Antibody (OAPB00317)Polyclonal Antibody
OPAN06667Recombinant SARS-CoV-2 Envelope Protein (OPAN06667)Recombinant Protein

ORF1a Polyprotein

The gene ORF1ab contains overlapping open reading frames that encode polyproteins PP1ab and PP1a. The polyproteins are cleaved to yield 16 nonstructural proteins, NSP1-16. SARS-CoV-2 nonstructural proteins are responsible for viral transcription, replication, proteolytic processing, suppression of host immune responses and suppression of host gene expression. The RNA-dependent RNA polymerase is a target of antiviral therapies. (Source NCBI)

Catalog NumberProduct NameType
OPGD00115Recombinant SARS-CoV-2 3C-like Proteinase Protein (OPGD00115)Recombinant Protein

Host ACE2 Angiotensin Converting Enzyme 2

ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. (Source RefSeq, Nov 2020)

Catalog NumberProduct NameType
OPSN00008Human Angiotensin-Converting Enzyme 2 Recombinant Protein (OPSN00008)Recombinant Protein
OPCA335977ACE2 Recombinant Protein (OPCA335977)Recombinant Protein
OPCA335985ACE2 Recombinant Protein (OPCA335985)Recombinant Protein
OPCD01026ACE2 Recombinant Protein (OPCD01026)Recombinant Protein
OPCD01027ACE2 Recombinant Protein (OPCD01027)Recombinant Protein
ARP53751_P050ACE2 Antibody - middle region (ARP53751_P050)Polyclonal Antibody
ARP53751_P050ACE2 Antibody - middle region (ARP53751_P050)Polyclonal Antibody
ARP86964_P050ACE2 Antibody - C-terminal region (ARP86964_P050)Polyclonal Antibody
OAAB16460ACE2 Antibody - N-terminal region (OAAB16460)Polyclonal Antibody
OAAB16464ACE2 Antibody - C-terminal region (OAAB16464)Polyclonal Antibody
OAAJ02844ACE2 Antibody (OAAJ02844)Polyclonal Antibody
OABF00360ACE2 Antibody (OABF00360)Polyclonal Antibody
OACA09680ACE2 Antibody (OACA09680)Polyclonal Antibody
OAGA01574ACE2 Antibody - N-terminal region (OAGA01574)Polyclonal Antibody
OAPB00213ACE2 Antibody (OAPB00213)Polyclonal Antibody
OAPB00219ACE2 Antibody (OAPB00219)Polyclonal Antibody
OAPB00220ACE2 Antibody (OAPB00220)Polyclonal Antibody
OASG00144ACE2 Antibody - middle region (OASG00144)Polyclonal Antibody
OALA08965ACE2 Antibody (OALA08965)Monoclonal Antibody
OKBB00649ACE2 ELISA Kit (Human) (OKBB00649)ELISA
OKBB00657ACE2 ELISA Kit (Mouse) (OKBB00657)ELISA
OKCD07767ACE2 ELISA Kit (Human) (OKCD07767)ELISA
OKCD07768ACE2 ELISA Kit (Mouse) (OKCD07768)ELISA
OKCD07769ACE2 ELISA Kit (Rat) (OKCD07769)ELISA
OKDD00949ACE2 ELISA Kit (Human) (OKDD00949)ELISA
OKDD00950ACE2 ELISA Kit (Mouse) (OKDD00950)ELISA
OKDD00951ACE2 ELISA Kit (Rat) (OKDD00951)ELISA
OKEH01348ACE2 ELISA Kit (Rat) : 96 Wells (OKEH01348)ELISA
OKEH02626ACE2 ELISA Kit (Human) : 96 Wells (OKEH02626)ELISA
OKEH06836ACE2 ELISA Kit (Mouse) (OKEH06836)ELISA