While Coronaviruses have been causing typical colds in humans for most of history, the recent emergence of SARS-CoV-2 and the resulting disease COVID-19 has inspired the research community to attack this pandemic with research on mechanisms of spread, infectivity, and viral mechanisms contributing to the pleiotropic effects of the disease. Aviva Systems Biology offers antibodies and recombinant proteins that may be useful for understanding the interactions of virus derived proteins that interact with host proteins, such as the Spike S1 interaction with the host ACE2 receptor. Antibodies and antibody pairs are useful for detection of viral proteins, and the recombinant Spike S1/RBD variants can be used as interaction probes to explore the consequence of viral mutation on the important host:protein interactions.
SARS-CoV-2 Antibody and Recombinant Protein Research Products
Targets: "S" Surface Glycoprotein | "N" Nucleocapsid | "E" Envelope Protein | ORF1a Polyprotein | ACE2
"S" Surface Glycoprotein
The spike glycoprotein is found on the outside of the virus particle and gives coronavirus viruses their crown-like appearance. This glycoprotein mediates attachment of the virus particle and entry into the host cell. S protein is an important target for vaccine development, antibody therapies and diagnostic antigen-based tests. (Source NCBI)
"S" Surface Glycoprotein Antibodies
| Catalog Number | Product Name | Type |
|---|---|---|
| OAPB00314 | SARS-CoV-2 Spike Antibody (OAPB00314) | Polyclonal Antibody |
| OAAQ00225 | SARS-CoV-2 Spike S1 (C-A11) Neutralizing Antibody (OAAQ00225) | Monoclonal Antibody |
| OAAN06661 | SARS-CoV-2 Spike Antibody (OAAN06661) | Monoclonal Antibody |
| OAAV00484 | COVID-19 & SARS-CoV S glycoprotein Antibody (OAAV00484) | Monoclonal Antibody |
| OAAV00485 | COVID-19 & SARS-CoV S glycoprotein Antibody (OAAV00485) | Monoclonal Antibody |
"S" Surface Glycoprotein Recombinant Proteins
"N" Nucleocapsid Phosphoprotein
The nucleocapsid phosphoprotein is a structural protein that binds to, protects the viral RNA genome and is involved in packaging the RNA into virus particles. The N protein has been suggested as an antiviral drug target. (Source NCBI)
"N" Nucleocapsid Antibodies
"N" Nucleocapsid Recombinant Proteins
"E" Envelope Protein
The envelope protein is found in virus particles. This protein facilitates assembly and release of the virus and has ion channel activity required for pathogenesis. (Source NCBI)
| Catalog Number | Product Name | Type |
|---|---|---|
| OAPB00317 | SARS-CoV-2 Envelope Antibody (OAPB00317) | Polyclonal Antibody |
| OPAN06667 | Recombinant SARS-CoV-2 Envelope Protein (OPAN06667) | Recombinant Protein |
ORF1a Polyprotein
The gene ORF1ab contains overlapping open reading frames that encode polyproteins PP1ab and PP1a. The polyproteins are cleaved to yield 16 nonstructural proteins, NSP1-16. SARS-CoV-2 nonstructural proteins are responsible for viral transcription, replication, proteolytic processing, suppression of host immune responses and suppression of host gene expression. The RNA-dependent RNA polymerase is a target of antiviral therapies. (Source NCBI)
| Catalog Number | Product Name | Type |
|---|---|---|
| OPGD00115 | Recombinant SARS-CoV-2 3C-like Proteinase Protein (OPGD00115) | Recombinant Protein |
Host ACE2 Angiotensin Converting Enzyme 2
ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. (Source RefSeq, Nov 2020)