MAPK Signaling

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

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MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology

 

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  1. Vinculin Antibody (OASL01260)
    Vinculin Antibody (OASL01260)
    Catalog #: OASL01260
    Protein Name: Vinculin
    Tested Species: Human
    Application: IHC-P
    Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    Size: 50ul
    Price:
    $239.00
  2. Vimentin Antibody (OASL01259)
    Vimentin Antibody (OASL01259)
    Catalog #: OASL01259
    Protein Name: Vimentin
    Tested Species: Human
    Application: IHC-P
    Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    Size: 50ul
    Price:
    $239.00
  3. Paraffin-embedded Appendix
    Villin Antibody (OASL01258)
    Catalog #: OASL01258
    Protein Name: Villin-1
    Alias: VIL
    Application: IHC-P
    Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    Size: 50ul
    Price:
    $239.00
  4. VEGF Antibody (OASL01257)
    VEGF Antibody (OASL01257)
    Catalog #: OASL01257
    Protein Name: Vascular Endothelial Growth Factor
    Tested Species: Human
    Application: IHC-P
    Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    Size: 50ul
    Price:
    $239.00
  5. Paraffin-embedded Bladder
    Uroplakin III Antibody (OASL01256)
    Catalog #: OASL01256
    Protein Name: Uroplakin-3a (UP3a) (Uroplakin III) (UPIII)
    Alias: UPK3
    Application: IHC-P
    Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    Size: 50ul
    Price:
    $239.00
  6. Tubulin beta Antibody (OASL01255)
    Tubulin beta Antibody (OASL01255)
    Catalog #: OASL01255
    Protein Name: Tubulin beta-3 chain
    Tested Species: Human
    Application: IHC-P
    Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    Size: 50ul
    Price:
    $239.00
  7. Tubulin a -PAN Antibody (OASL01254)
    Tubulin a -PAN Antibody (OASL01254)
    Catalog #: OASL01254
    Protein Name: Tubulin alpha-1A chain
    Tested Species: Human
    Application: IHC-P
    Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    Size: 50ul
    Price:
    $239.00
  8. Paraffin-embedded Gaint cell tumor
    TRAP Antibody (OASL01253)
    Catalog #: OASL01253
    Protein Name: Tartrate-resistant acid phosphatase type 5 (TR-AP) (EC 3.1.3.2) (Tartrate-resistant acid ATPase) (TrATPase) (Type 5 acid phosphatase)
    Alias: ACP5
    Application: IHC-P
    Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    Size: 50ul
    Price:
    $239.00
  9. Paraffin-embedded Follicular thyroid carcinoma
    TPO Antibody (OASL01252)
    Catalog #: OASL01252
    Protein Name: Thyroid peroxidase (TPO) (EC 1.11.1.8)
    Application: IHC-P
    Format: Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    Size: 50ul
    Price:
    $239.00
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