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MAPK Signaling

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

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MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology


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    RAP1B antibody - N-terminal region (ARP56194_P050) in Human PANC1 using Western Blot

    RAP1B antibody - N-terminal region (ARP56194_P050)

    Protein Name:Ras-related protein Rap-1b
    Catalog #:ARP56194_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $319.00
    PRKCB Antibody (OASA03763)

    PRKCB Antibody (OASA03763)

    Protein Name:Protein kinase C beta type
    Catalog #:OASA03763
    Type: mAb
    Reacts with:
    Application: IHC-AFF
    Product Size: 2ml
    Price (USD): $455.00
    Egf Antibody (OASA06527)

    Egf Antibody (OASA06527)

    Protein Name:Pro-epidermal growth factor
    Catalog #:OASA06527
    Type: pAb
    Reacts with: Mouse
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $590.00

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