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MAPK Signaling

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

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MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology

 

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    PLA2G2E antibody - middle region (ARP47041_P050) in Human Jurkat using Western Blot

    PLA2G2E Antibody - middle region (ARP47041_P050)

    Protein Name:Group IIE secretory phospholipase A2
    Catalog #:ARP47041_P050
    Type: pAb
    Reacts with: Cow, Horse, Human, Mouse
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    DUSP5 antibody - middle region (ARP58225_P050) in Human COLO205 using Western Blot

    DUSP5 Antibody - middle region (ARP58225_P050)

    Protein Name:Dual specificity protein phosphatase 5
    Catalog #:ARP58225_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    FGF14 antibody - middle region (ARP54710_P050) in Human Lung using Western Blot

    FGF14 Antibody - middle region (ARP54710_P050)

    Protein Name:Fibroblast growth factor 14
    Catalog #:ARP54710_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    CASP3 Antibody (OASA01038)

    CASP3 Antibody (OASA01038)

    Protein Name:Caspase-3
    Catalog #:OASA01038
    Type: mAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1ml
    Price (USD): $585.00
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    Prkar1a Antibody (OASA08703)

    Prkar1a Antibody (OASA08703)

    Protein Name:cAMP-dependent protein kinase type I-alpha regulatory subunit
    Catalog #:OASA08703
    Type: pAb
    Reacts with: Rat
    Application: WB
    Product Size: 0.1mg
    Price (USD): $760.00
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    HSPB1 Antibody (OASA02851)

    HSPB1 Antibody (OASA02851)

    Protein Name:Heat shock protein beta-1
    Catalog #:OASA02851
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, IHC-FFPE, WB
    Product Size: 1ml
    Price (USD): $1,055.00
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    HSPA8 Antibody (OASA06191)

    HSPA8 Antibody (OASA06191)

    Protein Name:Heat shock cognate 71 kDa protein
    Catalog #:OASA06191
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $530.00
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    Human AKT3 Antibody (OASA06009)

    Human AKT3 Antibody (OASA06009)

    Protein Name:RAC-gamma serine/threonine-protein kinase
    Catalog #:OASA06009
    Type: pAb
    Reacts with:
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $460.00
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    ECSIT Antibody - C-terminal region (OASA07228)

    ECSIT Antibody - C-terminal region (OASA07228)

    Protein Name:Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
    Catalog #:OASA07228
    Type: pAb
    Reacts with: Human
    Application: IHC-FFPE, WB
    Product Size: 0.1mg
    Price (USD): $355.00

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