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MAPK Signaling

The Mitogen-activated protein kinase (MAPK) pathway is a cellular pathway consisting of a large number of proteins that can be activated by a variety of extracellular stimuli. Activation of the MAPK pathway can result in a multitude of physiological effects, including apoptosis, cell proliferation, mitosis, and the transcription of several classes of genes. Although the specific intermediates of the MAPK pathway can vary dramatically depending on physiological state, cell type, and stimuli, the classical MAPK pathway operates in the following general sequence: external growth factors bind to a transmembrane protein receptor and this signal is propagated through RAS and Raf intermediates prior to phosphorylating three or more MAPKs in sequence. The MAPK pathway’s ubiquitous nature ensures that this pathway mediates the vast majority of cellular responses.
Aberrant MAPK activity, including constitutive activation or down-regulation, can lead to continuous and unregulated cellular proliferation or muted responses to external stimuli. As a result of its potential influence on such a wide variety of cellular processes, including signal transduction, amplification, and proliferation, the MAPK signaling pathway has been implicated in a broad range of diseases ranging from cancer to obesity. For instance, in many cancers, constitutively active MAPK signaling pathway components such as Ras and Raf induce cell proliferation in the absence of appropriate signals. Raf mutations have been identified in melanomas, thyroid, colorectal, and ovarian cancers[1]. Current research is focused on creating and evaluating the efficacy of many downstream MAPK modulators and inhibitors.

1. Wong. 2009. Recent developments in anti-cancer agents targeting the Ras/Raf/MEK/ERK Pathway. Recent Pat Anticancer Drug Discov. 4(1):28-35.

 See Related Product List Below Pathway Image

MAPK signaling pathway I image by Aviva Systems Biology

MAPK signaling pathway II image by Aviva Systems Biology

 

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    TRAF6 Antibody (OASA08876)

    TRAF6 Antibody (OASA08876)

    Protein Name:TNF receptor-associated factor 6
    Catalog #:OASA08876
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $315.00
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    PPP5C antibody - N-terminal region (ARP56695_P050) in Human Thymus using Western Blot

    PPP5C Antibody - N-terminal region (ARP56695_P050)

    Protein Name:Serine/threonine-protein phosphatase 5
    Catalog #:ARP56695_P050
    Type: pAb
    Reacts with: Cow, Guinea Pig, Human, Mouse, Pig, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    FGF2 Antibody (OASA02805)

    FGF2 Antibody (OASA02805)

    Protein Name:Fibroblast growth factor 2
    Catalog #:OASA02805
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, ELISA
    Product Size: 0.5 mg
    Price (USD): $569.00
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    SOS1 Antibody (OASA04400)

    SOS1 Antibody (OASA04400)

    Protein Name:Son of sevenless homolog 1
    Catalog #:OASA04400
    Type: mAb
    Reacts with: Human
    Application: ELISA, IF, WB
    Product Size: 0.1 mg
    Price (USD): $309.00
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    RAC2 Antibody (OASA06415)

    RAC2 Antibody (OASA06415)

    Protein Name:Ras-related C3 botulinum toxin substrate 2
    Catalog #:OASA06415
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $575.00
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    CHUK Antibody (OASA07831) in HeLa using Western Blot

    CHUK Antibody (OASA07831)

    Protein Name:Inhibitor of nuclear factor kappa-B kinase subunit alpha
    Catalog #:OASA07831
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $315.00
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    FAS Antibody (OASA02568) in HUT78 T using Flow Cytometry

    FAS Antibody (OASA02568)

    Protein Name:Tumor necrosis factor receptor superfamily member 6
    Catalog #:OASA02568
    Type: mAb
    Reacts with: Human
    Application: FC, IP
    Product Size: 0.2 mg
    Price (USD): $459.00
  •  
    CRK Protein Lysate (APL10439)

    CRK Protein Lysate (APL10439)

    Protein Name:Adapter molecule crk
    Catalog #:APL10439
    Type: Lysate
    Reacts with:
    Application:
    Product Size: 200ug
    Price (USD): $219.00
  •  
    FGF10 Antibody (OASA06164)

    FGF10 Antibody (OASA06164)

    Protein Name:Fibroblast growth factor 10
    Catalog #:OASA06164
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1 mg
    Price (USD): $609.00
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    NFKB1 Antibody (OASA08036)

    NFKB1 Antibody (OASA08036)

    Protein Name:Nuclear factor NF-kappa-B p105 subunit
    Catalog #:OASA08036
    Type: pAb
    Reacts with: Human
    Application: ELISA, GS, IP, WB
    Product Size: 0.1ml
    Price (USD): $770.00
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    MYC Antibody (OASA00538) in c-myc tagged protein using ELISA

    MYC Antibody (OASA00538)

    Protein Name:Myc proto-oncogene protein
    Catalog #:OASA00538
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, ELISA, FC, IHC-FFPE, WB
    Product Size: 1 mg
    Price (USD): $809.00
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    MAP3K7 Antibody (OASA06465)

    MAP3K7 Antibody (OASA06465)

    Protein Name:Mitogen-activated protein kinase kinase kinase 7
    Catalog #:OASA06465
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $545.00
  •  
    Mapk3 Antibody (OASA07240)

    Mapk3 Antibody (OASA07240)

    Protein Name:Mitogen-activated protein kinase 3
    Catalog #:OASA07240
    Type: pAb
    Reacts with: Rat
    Application: WB
    Product Size: 0.1 ml
    Price (USD): $750.00
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    IKBKB Antibody (OASA07837) in Jurkat using Western Blot

    IKBKB Antibody (OASA07837)

    Protein Name:Inhibitor of nuclear factor kappa-B kinase subunit beta
    Catalog #:OASA07837
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $315.00
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    PRKCA Antibody (OASA03762)

    PRKCA Antibody (OASA03762)

    Protein Name:Protein kinase C alpha type
    Catalog #:OASA03762
    Type: mAb
    Reacts with:
    Application: IHC-AFF, WB
    Product Size: 2 ml
    Price (USD): $509.00
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    BDNF Antibody (OASA07456)

    BDNF Antibody (OASA07456)

    Protein Name:Brain-derived neurotrophic factor
    Catalog #:OASA07456
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1 mg
    Price (USD): $609.00
  •  
    RELA Antibody (OASA08037)

    RELA Antibody (OASA08037)

    Protein Name:Transcription factor p65
    Catalog #:OASA08037
    Type: pAb
    Reacts with: Human
    Application: ELISA, IHC-FFPE, WB
    Product Size: 50 ug
    Price (USD): $469.00
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    TNF Antibody (OASA07352)

    TNF Antibody (OASA07352)

    Protein Name:Tumor necrosis factor
    Catalog #:OASA07352
    Type: pAb
    Reacts with: Horse
    Application: ELISA, WB
    Product Size: 0.5 mg
    Price (USD): $615.00
  •  
    Ngf Antibody (OASA08467)

    Ngf Antibody (OASA08467)

    Protein Name:Beta-nerve growth factor
    Catalog #:OASA08467
    Type: pAb
    Reacts with: Mouse
    Application: WB
    Product Size: 0.1ml
    Price (USD): $560.00
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    TGFBR2 antibody - N-terminal region (ARP44743_T100) in Human HepG2 using Western Blot

    TGFBR2 Antibody - N-terminal region (ARP44743_T100)

    Protein Name:TGF-beta receptor type-2
    Catalog #:ARP44743_T100
    Type: pAb
    Reacts with: Cow, Goat, Human, Mouse, Pig, Rabbit, Rat, Sheep
    Application: WB
    Product Size: 100 ul
    Price (USD): $249.00
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    JUND antibody - C-terminal region (ARP38602_P050) in Human Placenta using Western Blot

    JUND Antibody - C-terminal region (ARP38602_P050)

    Protein Name:Transcription factor jun-D
    Catalog #:ARP38602_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    Rapgef2 antibody - middle region (ARP42770_P050) in Mouse Kidney using Western Blot

    Rapgef2 Antibody - middle region (ARP42770_P050)

    Protein Name:Rap guanine nucleotide exchange factor 2 Ensembl ENSMUSP00000113778
    Catalog #:ARP42770_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    TGFB2 antibody - middle region (ARP45446_P050) in Human NCI-H226 using Western Blot

    TGFB2 Antibody - middle region (ARP45446_P050)

    Protein Name:Transforming growth factor beta-2
    Catalog #:ARP45446_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    RAC1 antibody - middle region (ARP57798_P050) in Human HepG2 using Western Blot

    RAC1 Antibody - middle region (ARP57798_P050)

    Protein Name:Ras-related C3 botulinum toxin substrate 1
    Catalog #:ARP57798_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $319.00
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    CACNA1G antibody - C - terminal region (ARP35566_P050) in Human Spleen using Western Blot

    CACNA1G Antibody - C - terminal region (ARP35566_P050)

    Protein Name:Voltage-dependent T-type calcium channel subunit alpha-1G
    Catalog #:ARP35566_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $319.00
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    RAP1B antibody - N-terminal region (ARP56194_P050) in Human PANC1 using Western Blot

    RAP1B Antibody - N-terminal region (ARP56194_P050)

    Protein Name:Ras-related protein Rap-1b
    Catalog #:ARP56194_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB, IHC
    Product Size: 100 ul
    Price (USD): $319.00
  •  
    CHP antibody - N-terminal region (ARP52307_P050) in Human 721_B using Western Blot

    CHP Antibody - N-terminal region (ARP52307_P050)

    Protein Name:Calcineurin B homologous protein 1
    Catalog #:ARP52307_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $319.00
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    PLA2G2E antibody - middle region (ARP47041_P050) in Human Jurkat using Western Blot

    PLA2G2E Antibody - middle region (ARP47041_P050)

    Protein Name:Group IIE secretory phospholipase A2
    Catalog #:ARP47041_P050
    Type: pAb
    Reacts with: Cow, Horse, Human, Mouse
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    DUSP5 antibody - middle region (ARP58225_P050) in Human COLO205 using Western Blot

    DUSP5 Antibody - middle region (ARP58225_P050)

    Protein Name:Dual specificity protein phosphatase 5
    Catalog #:ARP58225_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    GADD45B antibody - middle region (ARP48346_P050) in Human HepG2 using Western Blot

    GADD45B Antibody - middle region (ARP48346_P050)

    Protein Name:Growth arrest and DNA damage-inducible protein GADD45 beta
    Catalog #:ARP48346_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rat
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $319.00

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