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JAK-STAT

The Janus Kinase (Jak)- Signal Transducer and Activator of Transcription (STAT) signaling pathway converts extracellular signals into intracellular action such as cell migration, proliferation, and differentiation. Jak-STAT signaling is an evolutionarily conserved process that allows a cell to respond to a variety of growth and survival signals. There are three critical components of the Jak-STAT signaling pathway: a cytokine receptor, Jak, and STAT.

During Jak-STAT signaling, Jak will bind to a transmembrane cytokine receptor, which, upon ligand binding, will cause Jak to autophosphorylate. Jak phosphorylation encourages the recruitment of STAT molecules that are, in turn, phosphorylated by Jak. STAT molecules then form hetero- or homodimers and translocate to the nucleus to initiate transcription. There are seven different STAT molecules that interact with unique DNA sequences. Activation of Jaks associated with membrane receptors can also act as docking stations for secondary signaling molecules and adaptors that can link the Jak-STAT pathway to MAPK and other signaling pathways. Suppressors of cytokine signaling (SOCS) that compete with STAT binding sites on receptors and protein inhibitors of activated STAT (PIAS) that inhibit STAT binding to DNA negatively regulate the Jak-STAT pathway.

Jak mutations are hallmarks of many haematological malignancies. For instance, mutations in Jak3 that render it constitutively active can cause acute megakaryoblastic leukemia[1]. Similarly, STAT3, which is phosphorylated during IL-6 signaling, can be oncogenic if not properly controlled; STAT3 dysregulation, therefore, can continually promote an anti-apoptotic cellular milieu[2]. Considering the impact of dysregulated Jak-STAT signaling in a variety of diseases, including inflammatory disorders and malignancies, they are currently the focus of therapeutic intervention.  

1. Walters et al. 2006. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 10(1):65-75.
2. Sun et al. 2011. Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. Prostate. [epub ahead of print].

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    MYC Antibody (OASA00538) in c-myc tagged protein using ELISA

    MYC Antibody (OASA00538)

    Protein Name:Myc proto-oncogene protein
    Catalog #:OASA00538
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, FC, IHC-FFPE, WB
    Product Size: 1 mg
    Price (USD): $929.00
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    SOS1 Antibody (OASA04400)

    SOS1 Antibody (OASA04400)

    Protein Name:Son of sevenless homolog 1
    Catalog #:OASA04400
    Type: mAb
    Reacts with: Human
    Application: IF, WB
    Product Size: 0.1 mg
    Price (USD): $359.00
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    LEPR Antibody (OASA06331)

    LEPR Antibody (OASA06331)

    Protein Name:Leptin receptor
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    Price (USD): $709.00
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    IL4R Antibody (OASA03006)

    IL4R Antibody (OASA03006)

    Protein Name:Interleukin-4 receptor subunit alpha
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    Product Size: 0.1 mg
    Price (USD): $409.00
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    Il7 Antibody (OASA08443)

    Il7 Antibody (OASA08443)

    Protein Name:Interleukin-7
    Catalog #:OASA08443
    Type: pAb
    Reacts with: Mouse
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    Il2rb Antibody (OASA04861)

    Il2rb Antibody (OASA04861)

    Protein Name:Interleukin-2 receptor subunit beta
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    Il2 Antibody (OASA08671)

    Protein Name:Interleukin-2
    Catalog #:OASA08671
    Type: pAb
    Reacts with: Rat
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    Product Size: 0.1 mg
    Price (USD): $709.00
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    IL6R Antibody (OASA01186)

    IL6R Antibody (OASA01186)

    Protein Name:Interleukin-6 receptor subunit alpha
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    IL22RA1 antibody - N-terminal region (OASA06289) in human spleen using Immunohistochemistry

    IL22RA1 Antibody - N-terminal region (OASA06289)

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    Il2ra Antibody (OASA05092)

    Protein Name:Interleukin-2 receptor subunit alpha
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    CCND1 Antibody (OASA00562)

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    SPRY3 antibody - N-terminal region (ARP50519_P050) in Human Brain using Western Blot

    SPRY3 Antibody - N-terminal region (ARP50519_P050)

    Protein Name:Protein sprouty homolog 3
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    PIK3R3 Antibody (OASA03634)

    PIK3R3 Antibody (OASA03634)

    Protein Name:Phosphatidylinositol 3-kinase regulatory subunit gamma
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    Csf3 Antibody (OASA08399)

    Protein Name:Granulocyte colony-stimulating factor
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