JAK-STAT

The Janus Kinase (Jak)- Signal Transducer and Activator of Transcription (STAT) signaling pathway converts extracellular signals into intracellular action such as cell migration, proliferation, and differentiation. Jak-STAT signaling is an evolutionarily conserved process that allows a cell to respond to a variety of growth and survival signals. There are three critical components of the Jak-STAT signaling pathway: a cytokine receptor, Jak, and STAT.

During Jak-STAT signaling, Jak will bind to a transmembrane cytokine receptor, which, upon ligand binding, will cause Jak to autophosphorylate. Jak phosphorylation encourages the recruitment of STAT molecules that are, in turn, phosphorylated by Jak. STAT molecules then form hetero- or homodimers and translocate to the nucleus to initiate transcription. There are seven different STAT molecules that interact with unique DNA sequences. Activation of Jaks associated with membrane receptors can also act as docking stations for secondary signaling molecules and adaptors that can link the Jak-STAT pathway to MAPK and other signaling pathways. Suppressors of cytokine signaling (SOCS) that compete with STAT binding sites on receptors and protein inhibitors of activated STAT (PIAS) that inhibit STAT binding to DNA negatively regulate the Jak-STAT pathway.

Jak mutations are hallmarks of many haematological malignancies. For instance, mutations in Jak3 that render it constitutively active can cause acute megakaryoblastic leukemia[1]. Similarly, STAT3, which is phosphorylated during IL-6 signaling, can be oncogenic if not properly controlled; STAT3 dysregulation, therefore, can continually promote an anti-apoptotic cellular milieu[2]. Considering the impact of dysregulated Jak-STAT signaling in a variety of diseases, including inflammatory disorders and malignancies, they are currently the focus of therapeutic intervention.  

1. Walters et al. 2006. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 10(1):65-75.
2. Sun et al. 2011. Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. Prostate. [epub ahead of print].

  See Related Product List Below Pathway Image

JAKSTAT signaling pathway image by Aviva System Biology

 

Click here to download PDF and related products

Filter by Product Name
Page

Items 1-9 of 1135

per page
Set Descending Direction
  1. Hela cell lysate, A549 cell lysate, HepG2 cell lysate, Mouse brain tissue lysate, Mouse testis tissue lysate, Mouse liver tissue lysate, Rat brain tissue lysate, Rat testis tissue lysate, Rat liver tissue lysate
    Cyclin E1 Antibody (OASL01094)
    Catalog #: OASL01094
    Protein Name: G1/S-specific cyclin-E1
    Alias: CCNE1, CCNE, pcyclin E1
    Predicted Species: Human, Mouse, Rat
    Application: WB
    Format: Liquid. PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
    Size: 50ul
    Price:
    $239.00
  2. PC-3 cell lysate, HL-60 cell lysate, HCT116 cell lysate, Mouse heart tissue lysate, Mouse testis tissue lysate, Mouse cartilage tissue lysate, Rat heart tissue lysate, Rat testis tissue lysate, Rat cartilage tissue lysate
    RUNX2 Antibody (OASL01093)
    Catalog #: OASL01093
    Protein Name: Runt-related transcription factor 2
    Alias: AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA, runt related transcription factor 2
    Predicted Species: Human, Mouse, Rat
    Application: WB
    Format: Liquid. PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
    Size: 50ul
    Price:
    $239.00
  3. Mouse mixed tissue lysate
    CDK2 Antibody (OASL01092)
    Catalog #: OASL01092
    Protein Name: Cyclin-dependent kinase 2
    Alias: CDKN2, p33(CDK2)
    Predicted Species: Human, Mouse, Rat
    Application: WB
    Format: Liquid. PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
    Size: 50ul
    Price:
    $239.00
  4. Rat cell lysate
    Connexin 43/GJA1 Antibody (OASL01090)
    Catalog #: OASL01090
    Protein Name: Gap junction alpha-1 protein
    Alias: GJA1, AVSD3, CMDR, CX43, EKVP, GJAL, HLHS1, HSS, ODDD, PPKCA, gap junction protein alpha 1
    Predicted Species: Human, Mouse, Rat
    Application: WB
    Format: Liquid. PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
    Size: 50ul
    Price:
    $239.00
  5. Hela cell lysate, A549 cell lysate, MCF-7 cell lysate, Mouse heart tissue lysate, Mouse liver tissue lysate, Mouse brain tissue lysate, Rat heart tissue lysate, Rat liver tissue lysate, Rat brain tissue lysate,
    Beclin 1 Antibody (OASL01089)
    Catalog #: OASL01089
    Protein Name: Beclin-1
    Alias: BECN1, ATG6, VPS30, beclin1, beclin 1
    Predicted Species: Mouse, Rat
    Application: WB
    Format: Liquid. PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
    Size: 50ul
    Price:
    $239.00
  6. Rat brain tissue lysate
    Beclin 1 Antibody (OASL01088)
    Catalog #: OASL01088
    Protein Name: Beclin-1
    Alias: BECN1, ATG6, VPS30, beclin1, beclin-1, GT197
    Predicted Species: Human, Mouse, Rat
    Application: WB
    Format: Liquid. PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
    Size: 50ul
    Price:
    $239.00
  7. Human mixed cell lysate
    EGFR (Phospho-S1070) Antibody (OASL01087)
    Catalog #: OASL01087
    Protein Name: Epidermal growth factor receptor
    Alias: EGFR, ERBB, ERBB1, HER1, NISBD2, PIG61, mENA, epidermal growth factor receptor
    Predicted Species: Human
    Application: WB
    Format: Liquid. PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
    Size: 50ul
    Price:
    $239.00
  8. Hela cell lysate, HepG2 cell lysate, A431 cell lysate, Mouse spleen tissue lysate, Mouse skin tissue lysate, Mouse lung tissue lysate, Rat spleen tissue lysate, Rat skin tissue lysate, Rat lung tissue lysate
    IKB alpha Antibody (OASL01086)
    Catalog #: OASL01086
    Protein Name: NF-kappa-B inhibitor alpha
    Alias: NFKBIA, IKBA, MAD-3, NFKBI, NFKB inhibitor alpha
    Predicted Species: Human, Mouse, Rat
    Application: WB
    Format: Liquid. PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
    Size: 50ul
    Price:
    $239.00
  9. Hela cell lysate, HUVEC cell lysate, THP-1 cell lysate, Mouse heart tissue lysate, Mouse muscle tissue lysate, Mouse liver tissue lysate, Rat heart tissue lysate, Rat muscle tissue lysate, Rat liver tissue lysate
    Smad2 (Phospho-S425) Antibody (OASL01085)
    Catalog #: OASL01085
    Protein Name: Mothers against decapentaplegic homolog 2
    Alias: SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD family member 2
    Predicted Species: Mouse, Rat
    Application: WB
    Format: Liquid. PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
    Size: 50ul
    Price:
    $239.00
Page

Items 1-9 of 1135

per page
Set Descending Direction