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JAK-STAT

The Janus Kinase (Jak)- Signal Transducer and Activator of Transcription (STAT) signaling pathway converts extracellular signals into intracellular action such as cell migration, proliferation, and differentiation. Jak-STAT signaling is an evolutionarily conserved process that allows a cell to respond to a variety of growth and survival signals. There are three critical components of the Jak-STAT signaling pathway: a cytokine receptor, Jak, and STAT.

During Jak-STAT signaling, Jak will bind to a transmembrane cytokine receptor, which, upon ligand binding, will cause Jak to autophosphorylate. Jak phosphorylation encourages the recruitment of STAT molecules that are, in turn, phosphorylated by Jak. STAT molecules then form hetero- or homodimers and translocate to the nucleus to initiate transcription. There are seven different STAT molecules that interact with unique DNA sequences. Activation of Jaks associated with membrane receptors can also act as docking stations for secondary signaling molecules and adaptors that can link the Jak-STAT pathway to MAPK and other signaling pathways. Suppressors of cytokine signaling (SOCS) that compete with STAT binding sites on receptors and protein inhibitors of activated STAT (PIAS) that inhibit STAT binding to DNA negatively regulate the Jak-STAT pathway.

Jak mutations are hallmarks of many haematological malignancies. For instance, mutations in Jak3 that render it constitutively active can cause acute megakaryoblastic leukemia[1]. Similarly, STAT3, which is phosphorylated during IL-6 signaling, can be oncogenic if not properly controlled; STAT3 dysregulation, therefore, can continually promote an anti-apoptotic cellular milieu[2]. Considering the impact of dysregulated Jak-STAT signaling in a variety of diseases, including inflammatory disorders and malignancies, they are currently the focus of therapeutic intervention.  

1. Walters et al. 2006. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 10(1):65-75.
2. Sun et al. 2011. Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. Prostate. [epub ahead of print].

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    IL23R antibody - N-terminal region (OASA06290) in human spleen using Immunohistochemistry

    IL23R Antibody - N-terminal region (OASA06290)

    Protein Name:Interleukin-23 receptor
    Catalog #:OASA06290
    Type: pAb
    Reacts with: Human
    Application: IHC-FFPE, WB
    Product Size: 0.1 mg
    Price (USD): $509.00
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    MYC Antibody (OASA00538) in c-myc tagged protein using ELISA

    MYC Antibody (OASA00538)

    Protein Name:Myc proto-oncogene protein
    Catalog #:OASA00538
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, ELISA, FC, IHC-FFPE, WB
    Product Size: 1 mg
    Price (USD): $809.00
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    Il7 Antibody (OASA08443)

    Il7 Antibody (OASA08443)

    Protein Name:Interleukin-7
    Catalog #:OASA08443
    Type: pAb
    Reacts with: Mouse
    Application: ELISA, WB
    Product Size: 0.1 mg
    Price (USD): $609.00
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    EPO Antibody (OASA02761)

    EPO Antibody (OASA02761)

    Protein Name:Erythropoietin
    Catalog #:OASA02761
    Type: mAb
    Reacts with: Human
    Application: ELISA
    Product Size: 0.2 mg
    Price (USD): $459.00
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    Il2ra Antibody (OASA05092)

    Il2ra Antibody (OASA05092)

    Protein Name:Interleukin-2 receptor subunit alpha
    Catalog #:OASA05092
    Type: mAb
    Reacts with: Mouse
    Application: IHC-AFF, FC, IP
    Product Size: 0.25 mg
    Price (USD): $459.00
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    IL21R antibody - N-terminal region (OASA06288) in human lung using Immunohistochemistry

    IL21R Antibody - N-terminal region (OASA06288)

    Protein Name:Interleukin-21 receptor
    Catalog #:OASA06288
    Type: pAb
    Reacts with: Human
    Application: ELISA, IHC-FFPE
    Product Size: 0.1 mg
    Price (USD): $509.00
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    IL6 Antibody (OASA05650)

    IL6 Antibody (OASA05650)

    Protein Name:Interleukin-6
    Catalog #:OASA05650
    Type: mAb
    Reacts with: Mouse
    Application: ELISA
    Product Size: 0.5 mg
    Price (USD): $789.00
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    LEPR Antibody (OASA06331)

    LEPR Antibody (OASA06331)

    Protein Name:Leptin receptor
    Catalog #:OASA06331
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1 mg
    Price (USD): $609.00
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    CCND1 Antibody (OASA00562)

    CCND1 Antibody (OASA00562)

    Protein Name:G1/S-specific cyclin-D1
    Catalog #:OASA00562
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, ELISA, FC, IP, IHC-FFPE, WB
    Product Size: 0.1 mg
    Price (USD): $565.00
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    Lep Antibody (OASA08447)

    Lep Antibody (OASA08447)

    Protein Name:Leptin
    Catalog #:OASA08447
    Type: pAb
    Reacts with: Mouse
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $590.00
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    Il10ra Antibody (OASA05497)

    Il10ra Antibody (OASA05497)

    Protein Name:Interleukin-10 receptor subunit alpha
    Catalog #:OASA05497
    Type: mAb
    Reacts with: Mouse
    Application: FC
    Product Size: 0.25 mg
    Price (USD): $459.00
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    IL22RA1 antibody - N-terminal region (OASA06289) in human spleen using Immunohistochemistry

    IL22RA1 Antibody - N-terminal region (OASA06289)

    Protein Name:Interleukin-22 receptor subunit alpha-1
    Catalog #:OASA06289
    Type: pAb
    Reacts with: Human
    Application: ELISA, IF, IHC-FFPE
    Product Size: 0.1 mg
    Price (USD): $509.00
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    STAT3 Antibody - C-terminal region (OASA06855)

    STAT3 Antibody - C-terminal region (OASA06855)

    Protein Name:Signal transducer and activator of transcription 3
    Catalog #:OASA06855
    Type: pAb
    Reacts with: Human
    Application: IHC-AFF, ELISA, WB
    Product Size: 0.1 mg
    Price (USD): $609.00
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    SPRED2 antibody - C-terminal region (ARP60369_P050) in Human HepG2 using Western Blot

    SPRED2 Antibody - C-terminal region (ARP60369_P050)

    Protein Name:Sprouty-related, EVH1 domain-containing protein 2
    Catalog #:ARP60369_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
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    IL6ST Antibody (OASA01196)

    IL6ST Antibody (OASA01196)

    Protein Name:Interleukin-6 receptor subunit beta
    Catalog #:OASA01196
    Type: mAb
    Reacts with: Human
    Application: ELISA, FC
    Product Size: 0.1 mg
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    IL4R Antibody (OASA03006)

    IL4R Antibody (OASA03006)

    Protein Name:Interleukin-4 receptor subunit alpha
    Catalog #:OASA03006
    Type: mAb
    Reacts with: Human
    Application: ELISA, FC, IHC-FFPE, WB
    Product Size: 0.1 mg
    Price (USD): $615.00
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    IL28RA antibody - N-terminal region (ARP48070_P050) in Human HepG2 using Western Blot

    IL28RA Antibody - N-terminal region (ARP48070_P050)

    Protein Name:Interleukin-28 receptor subunit alpha
    Catalog #:ARP48070_P050
    Type: pAb
    Reacts with: Cow, Horse, Human, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
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    IL13RA2 antibody - middle region (ARP53558_P050) in Human HepG2 using Western Blot

    IL13RA2 Antibody - middle region (ARP53558_P050)

    Protein Name:Interleukin-13 receptor subunit alpha-2
    Catalog #:ARP53558_P050
    Type: pAb
    Reacts with: Human, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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