ATP11C Antibody - middle region (OAAB02861)
|Predicted Species Reactivity||Human, Mouse, Hamster|
|Product Format||Liquid. PBS with 0.09% (W/V) sodium azide.|
|Application||WB, FC, IHC-P|
|::||Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids (By similarity).
Cellular Location: Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in the presence of TMEM30B.
Tissue Location Widely expressed.
|Reconstitution and Storage||Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.|
|Replacement Item||This antibody may replace item sc-141337 from Santa Cruz Biotechnology.|
|Immunogen||This ATP11C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of human ATP11C.|
|Purification||This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Predicted Homology Based on Immunogen Sequence||Human; Mouse, Hamster|
|Concentration||Approximately 0.5mg/ml. Actual concentration varies with each lot.|
|Datasheets/Manuals||Printable datasheet for anti-ATP11C antibody - OAAB02861|
For research use only and not for use in diagnostic or therapeutic procedures.
|Application Info||WB: 1:1000
|Other Applications Image 1 Data||ATP11C Antibody (Center) flow cytometric analysis of 293 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.|
|Alias Symbols||ATP11C, ATPIQ, ATPIG, Probable phospholipid-transporting ATPase IG|
|NCBI Gene Id||286410|
|Protein Name||Probable phospholipid-transporting ATPase IG|
|Protein Accession #||NP_001010986.1|
|Molecular Weight||129477 Da|
|Tissue Tool||Find tissues and cell lines supported by DNA array analysis to express ATP11C.|
|RNA Seq||Find tissues and cell lines supported by RNA-seq analysis to express ATP11C.|
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