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Epigenetics

Epigenetics is the study of gene expression changes that result from processes that do not involve alteration of the DNA sequence. During embryogenesis, various epigenetic mechanisms play important roles in governing proper development, including chromatin remodeling and DNA methylation. Given that primary DNA sequences are not altered in a developing embryo, it is the epigenetic modifications that underlie the spatial and temporal control of gene expression. Hyper- and hypo-methylation of DNA can result in reduced and increased transcription of specific genes, respectively. Aberrant methylation patterns have been linked to the development and progression of a variety of cancers. Genomic imprinting is another epigenetic process that has been associated with human diseases, including Angelman Syndrome. Other epigenetic processes include histone acetylation and deacetylation, X chromosome inactivation, and heterochromatin regulation. While it is known that epigenetic changes can be maintained during cell division, evidence is mounting to support the notion that epigenetic marks can be transmitted from one generation to the next. Environmental factors such as stress and diet can have epigenetic consequences and these consequences may be passed on to offspring[1].

1. Waterland RA and Jirtle RL. 2003. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol. Aug; 23(15):5293-300.

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    CD6 antibody - C-terminal region (ARP63343_P050) in Human HCT15 using Western Blot

    CD6 Antibody - C-terminal region (ARP63343_P050)

    Protein Name:T-cell differentiation antigen CD6
    Catalog #:ARP63343_P050
    Type: pAb
    Reacts with: Cow, Dog, Human, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    MTA2 antibody - middle region (ARP35743_P050) in Human 721_B using Western Blot

    MTA2 Antibody - middle region (ARP35743_P050)

    Protein Name:Metastasis-associated protein MTA2
    Catalog #:ARP35743_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    Goat Anti-APBB1 / FE65 Antibody (OAEB01135) in NIH/3T3cells using Western Blot

    Goat Anti-APBB1 / FE65 Antibody (OAEB01135)

    Protein Name:Amyloid beta A4 precursor protein-binding family B member 1
    Catalog #:OAEB01135
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    SPIT2 Antibody (ARP49614_P050) in Human MCF7 Whole Cell using Western Blot

    SPINT2 Antibody - middle region (ARP49614_P050)

    Protein Name:kunitz-type protease inhibitor 2
    Catalog #:ARP49614_P050
    Type: pAb
    Reacts with: Cow, Horse, Human, Pig
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    Zbtb7a antibody - C-terminal region (ARP39212_P050) in Mouse Pancreas using Western Blot

    Zbtb7a Antibody - C-terminal region (ARP39212_P050)

    Protein Name:Zinc finger and BTB domain-containing protein 7A
    Catalog #:ARP39212_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    SALL1 Antibody (OAEB00032)

    SALL1 Antibody (OAEB00032)

    Protein Name:Sal-like protein 1
    Catalog #:OAEB00032
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: ELISA
    Product Size: 100 ug
    Price (USD): $229.00
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    COMT antibody - N-terminal region (OAEB02203) in human testiscells using Western Blot

    COMT Antibody - N-terminal region (OAEB02203)

    Protein Name:Catechol O-methyltransferase
    Catalog #:OAEB02203
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Rabbit
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    SMYD2 Antibody - middle region (ARP81568_P050) in Human Mesenchymoma Tumor using Western Blot

    SMYD2 Antibody - middle region (ARP81568_P050)

    Protein Name:N-lysine methyltransferase SMYD2
    Catalog #:ARP81568_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    SETD8 antibody - center region (OAAB03564) in 293 using Western Blot

    SETD8 Antibody - middle region (OAAB03564)

    Protein Name:N-lysine methyltransferase SETD8
    Catalog #:OAAB03564
    Type: pAb
    Reacts with: Cow, Human
    Application: WB, IHC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    NARF antibody - middle region (ARP54491_P050) in Human Liver using Western Blot

    NARF Antibody - middle region (ARP54491_P050)

    Protein Name:cDNA FLJ32404 fis, clone SKMUS2000380, highly similar to Homo sapiens nuclear prelamin A recognition factor (NARF), transcript variant 1, mRNA EMBL BAG51834.1
    Catalog #:ARP54491_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    Rdx antibody - C-terminal region (ARP56520_P050) in Mouse Small Intestine using Western Blot

    Rdx Antibody - C-terminal region (ARP56520_P050)

    Protein Name:Radixin
    Catalog #:ARP56520_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    SALL1 Antibody (OAEB00353)

    SALL1 Antibody (OAEB00353)

    Protein Name:Sal-like protein 1
    Catalog #:OAEB00353
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: ELISA
    Product Size: 100 ug
    Price (USD): $229.00
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    BHMT Antibody (OAEB02378) in Rat Livercells using Western Blot

    BHMT Antibody (OAEB02378)

    Protein Name:Betaine--homocysteine S-methyltransferase 1
    Catalog #:OAEB02378
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    POLE3 Antibody (N-term) (OAAB04304) in K562 using Western Blot

    POLE3 Antibody - N-terminal region (OAAB04304)

    Protein Name:DNA polymerase epsilon subunit 3
    Catalog #:OAAB04304
    Type: pAb
    Reacts with: Human
    Application: WB, FC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    RBBP4 Antibody - C-terminal region (ARP74776_P050) in Human HCT15 Whole Cell using Western Blot

    RBBP4 Antibody - C-terminal region (ARP74776_P050)

    Protein Name:histone-binding protein RBBP4
    Catalog #:ARP74776_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    POR Antibody (OAEB01434) in Rat Livercells using Western Blot

    POR Antibody (OAEB01434)

    Protein Name:NADPH--cytochrome P450 reductase PIRNR PIRNR000208
    Catalog #:OAEB01434
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    MBD3L2 Antibody - middle region (ARP66612_P050) in Human Placenta using Western Blot

    MBD3L2 Antibody - middle region (ARP66612_P050)

    Protein Name:Methyl-CpG-binding domain protein 3-like 2
    Catalog #:ARP66612_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    NCAPH antibody - N-terminal region (ARP46226_P050) in Human HepG2 using Western Blot

    NCAPH Antibody - N-terminal region (ARP46226_P050)

    Protein Name:Condensin complex subunit 2
    Catalog #:ARP46226_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    Pskh1 antibody - C-terminal region (ARP56720_P050) in Mouse Heart using Western Blot

    Pskh1 Antibody - C-terminal region (ARP56720_P050)

    Protein Name:Serine/threonine-protein kinase H1
    Catalog #:ARP56720_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    TADA2L antibody - N-terminal region (ARP38044_P050) in Human Jurkat using Western Blot

    TADA2L Antibody - N-terminal region (ARP38044_P050)

    Protein Name:Transcriptional adapter 2-alpha
    Catalog #:ARP38044_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    ALX3 Antibody (ARP36818_P050) in Human Thymus Tumor using Western Blot

    ALX3 Antibody - C-terminal region (ARP36818_P050)

    Protein Name:Homeobox protein aristaless-like 3
    Catalog #:ARP36818_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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