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Axon Guidance

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16. See Related Product List Below Pathway Image

Axon Guidance pathway image by Aviva System Biology

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    SEMA4D Antibody (OASA01062) in human peripheral blood lymphocytes using Flow Cytometry

    SEMA4D Antibody (OASA01062)

    Protein Name:Semaphorin-4D
    Catalog #:OASA01062
    Type: mAb
    Reacts with: Human
    Application: FC, IP, WB
    Product Size: 0.2mg
    Price (USD): $440.00
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    BRAT1 Antibody - C-terminal region (ARP62762_P050) in Human HepG2 using Western Blot

    BRAT1 Antibody - C-terminal region (ARP62762_P050)

    Protein Name:BRCA1-associated ATM activator 1
    Catalog #:ARP62762_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    UNC5A antibody - middle region (ARP50294_P050) in Human HeLa using Western Blot

    UNC5A Antibody - middle region (ARP50294_P050)

    Protein Name:Netrin receptor UNC5A
    Catalog #:ARP50294_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    SLIT1 antibody - middle region (ARP58765_P050) in Human Stomach using Western Blot

    SLIT1 Antibody - middle region (ARP58765_P050)

    Protein Name:Slit homolog 1 protein
    Catalog #:ARP58765_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $319.00
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    GNAI1 antibody - middle region (ARP54630_P050) in human thryoid using Western Blot

    GNAI1 Antibody - middle region (ARP54630_P050)

    Protein Name:Guanine nucleotide-binding protein G(i) subunit alpha-1
    Catalog #:ARP54630_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    CHP antibody - N-terminal region (ARP52307_P050) in Human 721_B using Western Blot

    CHP Antibody - N-terminal region (ARP52307_P050)

    Protein Name:Calcineurin B homologous protein 1
    Catalog #:ARP52307_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Product Size: 100 ul
    Price (USD): $319.00

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