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Axon Guidance

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16. See Related Product List Below Pathway Image

Axon Guidance pathway image by Aviva System Biology

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    SLIT3 antibody - N-terminal region (ARP58766_P050) in Jurkat using Western Blot

    SLIT3 antibody - N-terminal region (ARP58766_P050)

    Protein Name:Slit homolog 3 protein
    Catalog #:ARP58766_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    SEMA4B antibody - N-terminal region (ARP49485_P050) in Human Brain using Western Blot

    SEMA4B antibody - N-terminal region (ARP49485_P050)

    Protein Name:Semaphorin-4B
    Catalog #:ARP49485_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $319.00
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    Srgap1 antibody - middle region (ARP57446_P050) in Mouse Brain using Western Blot

    Srgap1 antibody - middle region (ARP57446_P050)

    Protein Name:SLIT-ROBO Rho GTPase-activating protein 1
    Catalog #:ARP57446_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    SEMA6D antibody - N-terminal region (ARP49584_P050) in Human 721_B using Western Blot

    SEMA6D antibody - N-terminal region (ARP49584_P050)

    Protein Name:Semaphorin-6D Ensembl ENSP00000453661 Ensembl ENSP00000348276
    Catalog #:ARP49584_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    SEMA4F antibody - N-terminal region (ARP46421_P050) in Transfected 293T using Western Blot

    SEMA4F antibody - N-terminal region (ARP46421_P050)

    Protein Name:Semaphorin-4F
    Catalog #:ARP46421_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    Sumo1 antibody - N-terminal region (ARP30639_P050) in Mouse Thymus using Western Blot

    Sumo1 antibody - N-terminal region (ARP30639_P050)

    Protein Name:Small ubiquitin-related modifier 1
    Catalog #:ARP30639_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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