Axon Guidance

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16. See Related Product List Below Pathway Image

Axon Guidance pathway image by Aviva System Biology

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  1. Human 786-0 Whole Cell
    SPAM1 Antibody - middle region (ARP64265_P050)
    Catalog #: ARP64265_P050
    Alias: SPAM1, HYAL3, PH20,
    Tested Species: Human
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    $319.00
  2. Human Adult Placenta
    SPAM1 Antibody - C-terminal region (ARP64264_P050)
    Catalog #: ARP64264_P050
    Protein Name: Hyaluronidase PH-20
    Alias: HYA1, HYAL1, HYAL3, HYAL5, MGC26532, PH-20, PH20, SPAG15
    Tested Species: Human
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  3. Mouse Thymus
    Sumo1 Antibody - N-terminal region (ARP30639_P050)
    Catalog #: ARP30639_P050
    Protein Name: Small ubiquitin-related modifier 1
    Alias: GMP1, MGC103203, PIC1, SENTRIN, SMT3, SMT3H3, SMTP3, SUMO-1, Smt3C, Ubl1
    Tested Species: Mouse
    Predicted Species: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  4. Mouse Brain
    Srgap1 Antibody - middle region (ARP57446_P050)
    Catalog #: ARP57446_P050
    Protein Name: SLIT-ROBO Rho GTPase-activating protein 1
    Alias: Arhgap13, 4930572H05Rik, Srgap1
    Tested Species: Mouse
    Predicted Species: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  5. SEMA7A Antibody (OASA02604)
    SEMA7A Antibody (OASA02604)
    Catalog #: OASA02604
    Protein Name: Semaphorin-7A
    Alias: JMH, CD108, SEMAL, CDw108, SEMAK1, H-Sema-L, H-SEMA-K1, MGC126692, MGC126696, SEMA7A
    Clone: MEM-150
    Predicted Species: Human
    Application: FC, IP, WB
    Format: Purified IgM - liquid
    Size: 0.2mg
    Price:
    $545.00
  6. Human peripheral blood lymphocytes
    SEMA4D Antibody (OASA01062)
    Catalog #: OASA01062
    Protein Name: Semaphorin-4D
    Alias: CD100, SEMAJ, coll-4, C9orf164, FLJ33485, FLJ34282, FLJ39737, FLJ46484, M-sema-G, MGC169138, MGC169141, SEMA4D
    Clone: A8
    Predicted Species: Human
    Application: FC, IP, WB
    Format: Purified IgG - liquid
    Size: 0.2mg
    Price:
    $440.00
  7. human A431
    SEMA4F Antibody - N-terminal region (ARP46421_P050)
    Catalog #: ARP46421_P050
    Protein Name: Semaphorin-4F
    Alias: SEMAM, SEMAW, M-SEMA, PRO2353, m-Sema-M
    Tested Species: Human
    Predicted Species: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
    Rating:
    80%
  8. Human Brain
    SEMA4B Antibody - N-terminal region (ARP49485_P050)
    Catalog #: ARP49485_P050
    Protein Name: Semaphorin-4B
    Alias: KIAA1745, MGC131831, SEMAC, SemC
    Tested Species: Human
    Predicted Species: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $319.00
  9. Human OVCAR-3
    SEMA6A Antibody - middle region (ARP49574_P050)
    Catalog #: ARP49574_P050
    Protein Name: Semaphorin-6A
    Alias: HT018, KIAA1368, SEMA, SEMA6A1, SEMAQ, VIA, sema VIa
    Tested Species: Human
    Predicted Species: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
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