Axon Guidance

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16. See Related Product List Below Pathway Image

Axon Guidance pathway image by Aviva System Biology

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  1. CDK5 Antibody - C-terminal region (OASA07137)
    CDK5 Antibody - C-terminal region (OASA07137)
    Catalog #: OASA07137
    Protein Name: Cyclin-dependent kinase 5
    Alias: PSSALRE, CDK5
    Predicted Species: Human
    Application: IP, WB
    Format: Serum - liquid
    Size: 50ul
    Price:
    $410.00
  2. Cxcl12 Antibody (OASA06686)
    Cxcl12 Antibody (OASA06686)
    Catalog #: OASA06686
    Protein Name: Stromal cell-derived factor 1
    Alias: Pbsf, Sdf1, Tlsf, Sdf1a, Sdf1b, Tlsfa, Tlsfb, Tpar1, Scyb12, AI174028, Cxcl12
    Predicted Species: Mouse
    Application: WB
    Format: Purified IgG - lyophilised
    Size: 0.1 mg
    Price:
    $709.00
  3. Cxcr4 Antibody - N-terminal region (OASA06519)
    Cxcr4 Antibody - N-terminal region (OASA06519)
    Catalog #: OASA06519
    Protein Name: C-X-C chemokine receptor type 4
    Alias: CD184, LESTR, Sdf1r, Cmkar4, PB-CKR, PBSF/SDF-1, Cxcr4
    Predicted Species: Mouse
    Application: IHC-FFPE, WB
    Format: Purified IgG - liquid
    Size: 0.1 mg
    Price:
    $589.00
  4. CFL2 Antibody - C-terminal region (OASA06111)
    CFL2 Antibody - C-terminal region (OASA06111)
    Catalog #: OASA06111
    Protein Name: Cofilin-2
    Alias: NEM7, CFL2
    Predicted Species: Human
    Application: WB
    Format: Purified IgG - liquid
    Size: 0.1mg
    Price:
    $545.00
  5. C-ABL Antibody (OASA00409)
    C-ABL Antibody (OASA00409)
    Catalog #: OASA00409
    Protein Name: Tyrosine-protein kinase ABL1
    Alias: ABL, JTK7, p150, c-ABL, v-abl, bcr/abl, ABL1
    Clone: 8E9
    Application: WB, IF, IP
    Format: Purified IgG - liquid
    Size: 0.1mg
    Price:
    $440.00
  6. Human Adult Liver
    CHP Antibody - N-terminal region (ARP52307_P050)
    Catalog #: ARP52307_P050
    Protein Name: Calcineurin B homologous protein 1
    Alias: SLC9A1BP, CHP
    Tested Species: Human
    Predicted Species: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: IHC, WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $319.00
  7. Human 721_B
    CDC42 Antibody - N-terminal region (AVARP01017_P050)
    Catalog #: AVARP01017_P050
    Protein Name: Cell division control protein 42 homolog
    Alias: CDC42Hs, G25K
    Tested Species: Human
    Predicted Species: Dog, Rabbit
    Application: WB, IHC
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00

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