Axon Guidance

Axon guidance refers to the process by which growing neural axons follow specific, predictable paths to reach their target locations. The tip of the growing axon is known as the growth cone and it is this part of the axon that senses guidance cues (also known as guidance factors) in the surrounding environment. The growth cone receptors respond to the various fixed and diffusible guidance cues and their gradients and respond accordingly. The response is in the form of directional changes in axon growth mediated by cytoskeletal changes. A broad array of signals can function as guidance cues, some of the most well-studied being Netrins, Ephrins and Semaphorins. Each guidance factor serves to attract or repel growth cones during neural development, although different cues can have diverse effects on distinct growth cones. It is the collective influence of the various cues that helps guide axons to their appropriate targets during development. The effects of guidance cues on axon growth can readily be studied in vitro with an array of commercially available factors. Elucidation of the processes that promote and inhibit axon growth during development may provide critical insights into neuroregenerative processes that could benefit patients with spinal cord injuries and other diseases of the nervous system[1].

1. Harel NY and Strittmatter SM. 2006. Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury? Nat Rev Neurosci. Aug;7(8):603-16. See Related Product List Below Pathway Image

Axon Guidance pathway image by Aviva System Biology

Please click here to download PDF and related products

Filter by Product Name
Page

Items 1-9 of 40

per page
Set Descending Direction
  1. Mouse Testis
    AMFR Antibody - N-terminal region (ARP88922_P050)
    Catalog #: ARP88922_P050
    Protein Name: E3 ubiquitin-protein ligase AMFR
    Alias: gp78
    Tested Species: Mouse
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  2. Human 786-0 Whole Cell
    SPAM1 Antibody - middle region (ARP64265_P050)
    Catalog #: ARP64265_P050
    Alias: SPAM1, HYAL3, PH20,
    Tested Species: Human
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    $319.00
  3. Human Adult Placenta
    SPAM1 Antibody - C-terminal region (ARP64264_P050)
    Catalog #: ARP64264_P050
    Protein Name: Hyaluronidase PH-20
    Alias: HYA1, HYAL1, HYAL3, HYAL5, MGC26532, PH-20, PH20, SPAG15
    Tested Species: Human
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  4. Human HeLa
    ADGRL1 Antibody - C-terminal region (ARP65781_P050)
    Catalog #: ARP65781_P050
    Protein Name: adhesion G protein-coupled receptor L1
    Alias: CL1, LEC2, CIRL1, LPHN1
    Tested Species: Human
    Predicted Species: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  5. Human HepG2
    BRAT1 Antibody - C-terminal region (ARP62762_P050)
    Catalog #: ARP62762_P050
    Protein Name: BRCA1-associated ATM activator 1
    Alias: MGC22916, BAAT1, C7orf27
    Tested Species: Human
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  6. Mouse Liver
    JUN Antibody - middle region (ARP30926_P050)
    Catalog #: ARP30926_P050
    Protein Name: Transcription factor AP-1
    Alias: AP-1, AP1, c-Jun
    Tested Species: Human, Mouse, Sea Urchin
    Predicted Species: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
    Rating:
    80%
  7. Mouse Thymus
    Sumo1 Antibody - N-terminal region (ARP30639_P050)
    Catalog #: ARP30639_P050
    Protein Name: Small ubiquitin-related modifier 1
    Alias: GMP1, MGC103203, PIC1, SENTRIN, SMT3, SMT3H3, SMTP3, SUMO-1, Smt3C, Ubl1
    Tested Species: Mouse
    Predicted Species: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  8. Human Placenta
    EFNA2 Antibody - middle region (ARP61345_P050)
    Catalog #: ARP61345_P050
    Protein Name: Ephrin-A2
    Alias: ELF-1, EPLG6, HEK7-L, LERK6, LERK-6
    Tested Species: Human, Mouse
    Predicted Species: Cow, Guinea Pig, Human, Mouse, Rat
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  9. Mouse Heart
    Ppp3cb Antibody - C-terminal region (ARP57516_P050)
    Catalog #: ARP57516_P050
    Protein Name: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
    Alias: 1110063J16Rik, Calnb, CnAbeta, Cnab
    Tested Species: Mouse
    Predicted Species: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
Page

Items 1-9 of 40

per page
Set Descending Direction