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RCOR1 Antibody - N-terminal region (OAAB12433)

400ul
$390.00
In Stock
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Predicted Species Reactivity:
Human, Mouse
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Ig
Host:
Rabbit
Application:
WB
Additional Information:
Precautions: RCOR1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
:::
Function: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation
:::
Cellular Location: Nucleus. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner
Tissue Location: Ubiquitously expressed.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
RCOR1
NCBI Gene Id:
23186
Protein Name:
REST corepressor 1
Swissprot Id:
Q9UKL0
Protein Accession #:
NP_055971.2
Alias Symbols:
RCOR1, KIAA0071, RCOR, REST corepressor 1, Protein CoREST
Description of Target:
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Molecular Weight:
53028 Da
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express RCOR1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express RCOR1.
Immunogen:
This RCOR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-130 amino acids from the N-terminal region of human RCOR1.
Predicted Homology Based on Immunogen Sequence:
Human; Mouse
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for OAAB12433
Sample Type Confirmation:

RCOR1 is strongly supported by BioGPS gene expression data to be expressed in ZR75-1

Application Info:
WB: 1:2000
WB: 1:1000

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