- Predicted Species Reactivity:
- Human, Mouse
- Product Format:
- Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
- Clonality:
- Polyclonal
- Isotype:
- Ig
- Host:
- Rabbit
- Application:
- WB
- Additional Information:
- Precautions: RCOR1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
- :::
- Function: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation
- :::
- Cellular Location: Nucleus. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner
Tissue Location: Ubiquitously expressed. - Reconstitution and Storage:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Gene Symbol:
- RCOR1
- NCBI Gene Id:
- 23186
- Protein Name:
- REST corepressor 1
- Swissprot Id:
- Q9UKL0
- Protein Accession #:
- NP_055971.2
- Alias Symbols:
- RCOR1, KIAA0071, RCOR, REST corepressor 1, Protein CoREST
- Description of Target:
- Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
- Molecular Weight:
- 53028 Da
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express RCOR1.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express RCOR1.
- Immunogen:
- This RCOR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-130 amino acids from the N-terminal region of human RCOR1.
- Predicted Homology Based on Immunogen Sequence:
- Human; Mouse
- Concentration:
- Approximately 0.5mg/ml. Actual concentration varies with each lot.
- Datasheets/Manuals:
- Printable datasheet for OAAB12433
- Sample Type Confirmation:
RCOR1 is strongly supported by BioGPS gene expression data to be expressed in ZR75-1
- Application Info:
- WB: 1:2000
WB: 1:1000
Product Reviews
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