RCOR1 Antibody - N-terminal region (OAAB12433)

Catalog#: OAAB12433

• Size: 400ul

• Predicted Species Reactivity: Human, Mouse
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
• Additional Information: Precautions: RCOR1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation
  Cellular Location: Nucleus. Note=Upon infection by HSV-1, it is partially translocated into the cytoplasm in an HSV-1-dependent manner
  Tissue Location: Ubiquitously expressed.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Gene Symbol: RCOR1
• NCBI Gene Id: 23186
• Protein Name: REST corepressor 1
• Swissprot Id: Q9UKL0
• Protein Accession #: NP_055971.2
• Alias Symbols: RCOR1, KIAA0071, RCOR, REST corepressor 1, Protein CoREST
• Description of Target: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Molecular Weight: 53028 Da
• RNA Seq: Find tissues and cell lines supported by RNA-seq analysis to express RCOR1.
• Immunogen: This RCOR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-130 amino acids from the N-terminal region of human RCOR1.
• Predicted Homology Based on Immunogen Sequence: Human; Mouse
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Sample Type Confirmation:

  RCOR1 is strongly supported by BioGPS gene expression data to be expressed in ZR75-1

• Application Info: WB: 1:2000
  WB: 1:1000

Protocol:

Tips Information:

Product Protocol: RCOR1 antibody tested with human ZR-75-1 by western blot (OAAB12433)