RCAN2 Antibody (OAPB00840)

Catalog No: OAPB00840

Size:100UG

Western blot analysis of RCAN2 in 3T3 cell lysate with RCAN2 antibody at (A) 1 and (B) 2 ug/mL.

Immunohistochemistry of RCAN2 in mouse brain tissue with RCAN2 antibody at 2.5 ug/mL.

Product Info

• Predicted Species Reactivity: Bovine|Human|Mouse|Rat
• Product Format: Liquid. RCAN2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: RCAN2 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: RCAN2 antibody was raised against a 14 amino acid synthetic peptide near the center of human RCAN2. The immunogen is located within amino acids 70 - 120 of RCAN2.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-RCAN2 antibody is Catalog # OEPB02959
• Application Info: RCAN2 antibody can be used for detection of RCAN2 by Western blot at 1 - 2 ug/ml. (Optimal dilution should be determined by user)
• Reference: Miyazaki T, Kanou Y, Murata Y, et al. Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts. J. Biol. Chem.1996; 271:14567-71.;Rothermal B, Vega RB, Yang J, et al. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J. Biol. Chem.2000; 275:8719-25.;Cao X, Kambe F, Miyazaki Y, et al. Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors. Biochem. J.2002; 367:459-66.;Fuentes JJ, Genesca L, Kingsbury TJ, et al. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum. Mol. Genet.2000; 9:1681-90.

Target Info

• Gene Symbol: Rcan2
• Gene Full Name: regulator of calcineurin 2
• Alias Symbols: calcineurin inhibitory protein ZAKI-4;calcipressin-2;Cs;Csp2;down syndrome candidate region 1-like protein 1;Down syndrome critical region gene 1-like 1;Dscr;Dscr1l1;MCI;MCIP2;myocyte-enriched calcineurin interactin protein 2;myocyte-enriched calcineurin-interacting protein 2;Regulator of calcineurin 2;ZAKI;ZAKI-4.
• NCBI Gene Id: 53901
• Protein Name: Calcipressin-2|Rcan2 protein [Mus musculus]
• Description of Target: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
• Uniprot ID: Q9JHG2
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/AAH62141