Mouse CD117 Antibody (OASB02295)

Catalog No: OASB02295

Size:500UG

Product Info

• Tested Species Reactivity: Mouse
• Predicted Species Reactivity: Mouse
• Product Format: Liquid. Borate buffered saline, pH 8.2
• Clonality: Monoclonal
• Host: Rat
• Conjugation: Unconjugated
• Application: FC, IP
• Additional Information: Description: The CD117 (c-Kit) antigen is the cell-surface receptor for stem cell factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. SCF/c-Kit also participates in erythropoiesis in both the bone marrow and spleen. Loss-of-function mutations for SCF/c-Kit lead to a variety of pleiotropic developmental defects while gain-of-function mutations can lead to constitutive activation of the kit receptor and links to cancer. Examples of the former are mast cell deficiency and severe macrocytic anemia while the latter mutation has been identified in mastocytomas.
• Reconstitution and Storage: Store at 2-8C
• Immunogen: Mouse IL-3-dependent bone marrow mast cells
• Concentration: 0.5 mg/mL
• Specificity: CD117

Target Info

• Gene Symbol: KIT
• Gene Full Name: KIT proto-oncogene receptor tyrosine kinase
• Alias Symbols: W, Bs, SC, SO, Fdc, Ssm, Gsfs, SCO1, SCO5, SOW3, Tr-k, c-KI, CD117, belly, c-KIT, Tr-kit, Gsfsco1, Gsfsco5, Gsfsow3
• NCBI Gene Id: 16590
• Protein Name: mast/stem cell growth factor receptor Kit
• Description of Target: The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Uniprot ID: P05532
• Protein Accession #: NP_001116205.1
• Nucleotide Accession #: NM_001122733.1