RASAL1 Antibody - middle region (OAAB08730)

Catalog No: OAAB08730

Size:400ul

RASAL1 Antibody (Center) (Cat. #OAAB08730) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the RASAL1 antibody detected the RASAL1 protein (arrow).

Product Info

• Predicted Species Reactivity: Mouse
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
  Function: Probable inhibitory regulator of the Ras-cyclic AMP pathway. Plays a role in dendrite formation by melanocytes.
  Tissue Location: Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea. Expressed in melanocytes.
  
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This RASAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-337 amino acids from the Central region of human RASAL1.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Predicted Homology Based on Immunogen Sequence: Mouse
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Intended Use: RASAL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:1000

Target Info

• Gene Symbol: RASAL1
• Alias Symbols: RASAL
• NCBI Gene Id: 8437
• Protein Name: RasGAP-activating-like protein 1
• Description of Target: The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described.
• Uniprot ID: O95294
• Protein Accession #: NP_001180450.1
• Molecular Weight: 90016 Da