Search Antibody, Protein, and ELISA Kit Solutions

RASA1 Antibody - N-terminal region : FITC (ARP74173_P050-FITC)

100 ul
$289.00
In Stock
Request Bulk Order Quote

Conjugation Options

ARP74173_P050 Unconjugated

ARP74173_P050-HRP Conjugated

ARP74173_P050-Biotin Conjugated

Gene Symbol:
RASA1
NCBI Gene Id:
5921
Swissprot Id:
P20936
Alias Symbols:
RASA1, GAP, RASA,
Replacement Item:
This antibody may replace item sc-271436 from Santa Cruz Biotechnology.
Description of Target:
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
Protein Size (# AA):
1047
Molecular Weight:
115kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express RASA1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express RASA1.
Immunogen:
The immunogen is a synthetic peptide directed towards the N-terminal region of Human RASA1
Predicted Species Reactivity:
Human
Peptide Sequence:
Synthetic peptide located within the following region: GTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGK
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution and Storage:
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Concentration:
0.5 mg/ml
Protein Interactions:
ARHGAP35; DOK1; KHDRBS1; DOK2; PLCG1; EGFR; ABL1; Mbp; ERBB4; ERBB3; ERBB2; APP; SOCS1; UBC; SPSB1; ZNF579; BBS10; TRMT2A; EIF1; SERPINA4; XRCC6; EZH2; NCK1; BTRC; NFKBIA; DOK4; AFAP1L2; DNAJA3; G3BP1; PAG1; AURKB; MAP4K4; SOCS3; BIRC5; ARHGAP1; ARHGAP5;
Blocking Peptide:
For anti-RASA1 (ARP74173_P050-FITC) antibody is Catalog # AAP74173
Datasheets/Manuals:
Printable datasheet for anti-RASA1 (ARP74173_P050-FITC) antibody
Conjugation:
FITC (FAM): Excitation 495 nm/ Emission 520 nm

Product Reviews

Tell us what you think about this item!

Write A Review
    Please, wait...