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Catalog No: OAAB16216
Size:400ul
Price: $419.00
SKU
OAAB16216
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for OAAB16216
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid. PBS with 0.09% (W/V) sodium azide.
ClonalityPolyclonal
IsotypeIg
HostRabbit
ApplicationDB
::Function: Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates mTORC1 is activated in response to growth factors or amino acids Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for ciliogenesis.
Cellular Location: Cytoplasm. Lysosome. Cytoplasmic granule. Note=Targeting to lysosomes depends on amino acid availability. In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased.
Tissue Location: Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta. Isoform 3 is widely expressed, with highest levels in nasal mucosa and pituitary and lowest in spleen.
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis Raptor Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S863 of human Raptor.
PurificationThis antibody is purified through a protein A column, followed by peptide affinity purification.
Predicted Homology Based on Immunogen SequenceHuman
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Intended Use
For research use only and not for use in diagnostic or therapeutic procedures.
Application InfoDB: 1:500
Gene SymbolRPTOR
Alias SymbolsKOG1, Mip1
NCBI Gene Id57521
Protein NameRegulatory-associated protein of mTOR
Description of TargetRaptor participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). It plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. It has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, raptor serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.
Uniprot IDQ8N122
Protein Accession #NP_065812.1
Molecular Weight149038 Da
  1. What is the species homology for "Raptor Antibody (Phospho-Ser863) (OAAB16216)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "Raptor Antibody (Phospho-Ser863) (OAAB16216)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "Raptor Antibody (Phospho-Ser863) (OAAB16216)" provided in?

    This item is provided in "Liquid. PBS with 0.09% (W/V) sodium azide. ".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "Raptor Antibody (Phospho-Ser863) (OAAB16216)"?

    This target may also be called "KOG1, Mip1" in publications.

  5. What is the shipping cost for "Raptor Antibody (Phospho-Ser863) (OAAB16216)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "Raptor Antibody (Phospho-Ser863) (OAAB16216)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "Raptor Antibody (Phospho-Ser863) (OAAB16216)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "149038 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "Raptor Antibody (Phospho-Ser863) (OAAB16216)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "RPTOR"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "RPTOR"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "RPTOR"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "RPTOR"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "RPTOR"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "RPTOR"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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