Catalog No: OAAF01912 (Formerly GWB-ASD182)
Size:100 ug
Price: $344.00
SKU
OAAF01912
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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Datasheets/ManualsPrintable datasheet for RAN Antibody (OAAF01912)
Product Info
ReferenceKaren M. Lounsbury, J. Biol. Chem., Feb 1996; 271: 2357.
Gretchen A. Murphy, Mol. Biol. Cell, Dec 1997; 8: 2591.
Francisco J. Nicolás, J. Cell Sci., Aug 2001; 114: 3013.
Petr Kalab, Science, Mar 2002; 295: 2452.
Predicted Species ReactivityHuman|Mouse|Rat
Product FormatLiquid
ClonalityPolyclonal
HostRabbit
ApplicationELISA, IF, IHC, IHC-P, WB
Reconstitution and Storage-20°C
ImmunogenThe antiserum was produced against synthesized peptide derived from human RAN.
PurificationThe antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
SpecificityRAN antibody detects endogenous levels of total RAN protein.
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
DilutionThe optimal working dilution should be determined by the end user.
Application InfoWB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000
Gene SymbolRAN
Gene Full NameRAN, member RAS oncogene family
Alias Symbolsandrogen receptor-associated protein 24;ARA24;Gsp1;GTPase Ran;GTP-binding nuclear protein Ran;guanosine triphosphatase Ran;member RAS oncogene family;RanGTPase;ras-like protein TC4;ras-related nuclear protein;TC4.
NCBI Gene Id5901
Protein NameGTP-binding nuclear protein Ran
Description of TargetGTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs (PubMed:10400640, PubMed:8276887, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:26272610). Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis (PubMed:7819259, PubMed:8896452, PubMed:8636225, PubMed:8692944, PubMed:9351834, PubMed:9428644, PubMed:9822603, PubMed:29040603, PubMed:11336674, PubMed:26272610). Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport (PubMed:8896452, PubMed:9351834, PubMed:9428644). Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation (PubMed:10408446, PubMed:29040603). Required for normal progress through mitosis (PubMed:8421051, PubMed:12194828, PubMed:29040603). The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640).
Uniprot IDP62826
Protein Accession #NP_006316.1
Molecular Weight24 kDa
  1. What is the species homology for "RAN Antibody (OAAF01912)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".

  2. How long will it take to receive "RAN Antibody (OAAF01912)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "RAN Antibody (OAAF01912)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "RAN Antibody (OAAF01912)"?

    This target may also be called "androgen receptor-associated protein 24;ARA24;Gsp1;GTPase Ran;GTP-binding nuclear protein Ran;guanosine triphosphatase Ran;member RAS oncogene family;RanGTPase;ras-like protein TC4;ras-related nuclear protein;TC4." in publications.

  5. What is the shipping cost for "RAN Antibody (OAAF01912)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "RAN Antibody (OAAF01912)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "RAN Antibody (OAAF01912)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "24 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "RAN Antibody (OAAF01912)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "RAN"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "RAN"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "RAN"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "RAN"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "RAN"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "RAN"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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