RALBP1 Antibody - N-terminal region (ARP52251_P050)

Catalog No: ARP52251_P050

WB Suggested Anti-RALBP1 Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysate

Rabbit Anti-RALBP1 Antibody
Catalog Number: ARP52251_P050
Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue
Observed Staining: Plasma membrane in intercalated disk
Primary Antibody Concentration: 1:100
Other Working Concentrations: N/A
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RALBP1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Goat: 86%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: MTECFLPPTSSPSEHRRVEHGSGLTRTPSSEEISPTKFPGLYRTGEPSPP
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-RALBP1 (ARP52251_P050) antibody is Catalog # AAP52251 (Previous Catalog # AAPP44018)

Target Info

• Gene Symbol: RALBP1
• Gene Full Name: RalA binding protein 1
• Alias Symbols: RIP1, RLIP1, RLIP76
• NCBI Gene Id: 10928
• Protein Name: RalA-binding protein 1
• Description of Target: RALBP1 can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. RALBP1 mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes.RALBP1 can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. RALBP1 serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
• Uniprot ID: Q15311
• Protein Accession #: NP_006779
• Nucleotide Accession #: NM_006788
• Protein Size (# AA): 655
• Molecular Weight: 76kDa
• Protein Interactions: TNIP1; CEP57; SMARCE1; PPL; GPS2; GSE1; ZNF707; ZBTB38; C1orf216; TBRG1; AMOTL2; TFPT; UBC; RALB; GPSM1; PRKCA; CPSF2; POLR2A; AP2A1; SYNJ2BP; HOOK2; REPS1; FADD; RAC1; TRAF2; CASP8; AP2M1; REPS2; IKBKG; RALA; CCNB1; HSP90AA1; HSF1; EPN1; NUMB; GTF3A; TNF