Search Antibody, Protein, and ELISA Kit Solutions

RAD51 Antibody (OAAB22017)

100 ul
$390.00
In Stock
Request Bulk Order Quote

Gene Symbol:
RAD51
NCBI Gene Id:
5888
Official Gene Full Name:
RAD51 recombinase
Swissprot Id:
Q06609
Protein Accession #:
NP_001157741.1
Nucleotide Accession #:
NM_001164269.1
Alias Symbols:
RECA, BRCC5, FANCR, MRMV2, HRAD51, RAD51A, HsRad51, HsT16930
Replacement Item:
This antibody may replace item sc-36360 from Santa Cruz Biotechnology.
Description of Target:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
Molecular Weight:
37 kDa
Host:
Rabbit
Clonality:
Monoclonal
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express RAD51.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express RAD51.
Predicted Species Reactivity:
Human, Mouse
Predicted Homology Based on Immunogen Sequence:
Human, Mouse
Product Format:
Liquid
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals:
Printable datasheet for anti-RAD51 (OAAB22017) antibody
Preservative:
0.03% Proclin300 and 50% glycerol
Formulation:
0.03% Proclin300 and 50% glycerol.
Application Info:
WB: 1:1000
Additional Information:
Function: Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2- scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.
Target Reference:
Shinohara A.,et al.Nat. Genet. 4:239-243(1993).
Yoshimura Y.,et al.Nucleic Acids Res. 21:1665-1665(1993).
Schmutte C.,et al.Cancer Res. 59:4564-4569(1999).
Wang W.W.,et al.Cancer Epidemiol. Biomarkers Prev. 10:955-960(2001).
Park J.Y.,et al.Nucleic Acids Res. 36:3226-3234(2008).

Product Reviews

Protocol:
Tips Information:

Tell us what you think about this item!

Write A Review
    Please, wait...