Rabbit anti-humanGrowth/differentiation factor 15 (OACA01684)

Catalog No: OACA01684

Size:100ug

All lanes : Growth/differentiation factor 15 antibody at 2 µg/ml
Lane 1 :EC109 whole cell lysate
Lane 2 :293T whole cell lysate
Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size : 34kDa
Observed band size: 34kDa

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Growth/differentiation factor 15 protein (198-308AA)
• Purification: Protein G Purified
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Reference: [1] PLAB, a novel placental bone morphogenetic protein.'Hromas R., Hufford M., Sutton J., Xu D., Li Y., Lu L.Biochim. Biophys. Acta 1354:40-44(1997)
  [2] Human cDNA encoding a novel TGF-beta superfamily protein highly expressed in placenta.'Yokoyama-Kobayashi M., Saeki M., Sekine S., Kato S.J. Biochem. 122:622-626(1997)
  [3] MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily.'Bootcov M.R., Bauskin A.R., Valenzuela S.M., Moore A.G., Bansal M., He X.Y., Zhang H.P., Donnellan M., Mahler S., Pryor K., Walsh B.J., Nicholson R.C., Fairlie W.D., Por S.B., Robbins J.M., Breit S.N.Proc. Natl. Acad. Sci. U.S.A. 94:11514-11519(1997)
• Storage Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Target Info

• Gene Symbol: GDF15
• Gene Full Name: growth differentiation factor 15
• Alias Symbols: GDF-15;growth/differentiation factor 15;macrophage inhibitory cytokine 1;MIC1;MIC-1;NAG-1;non-steroidal anti-inflammatory drug-activated gene-1;NRG-1;NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1;NSAID-activated gene 1 protein;NSAID-regulated gene 1 protein;PDF;PLAB;placental bone morphogenetic protein;placental TGF-beta;prostate differentiation factor;PTGFB;PTGF-beta.
• NCBI Gene Id: 9518
• Protein Name: Growth/differentiation factor 15
• Description of Target: Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:23468844, PubMed:29046435). Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions (PubMed:28953886). On hepatocytes, inhibits growth hormone signaling (By similarity).
• Uniprot ID: Q99988