Rabbit anti-human Proteasome subunit beta type-2 (OACA00629)

Catalog No: OACA00629

Size:100ug

Immunohistochemistry of paraffin-embedded mouse kidney using OACA00629 at dilution 1:50
 

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Western blot
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Proteasome subunit beta type-2 protein (1-201AA)
• Purification: Protein G Purified
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Reference: [1] Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues.'Nothwang H.G., Tamura T., Tanaka K., Ichihara A.Biochim. Biophys. Acta 1219:361-368(1994)
  [2] Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).'Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
  [3] Cloning of human full-length CDSs in BD Creator(TM) system donor vector.'Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
  [4] The DNA sequence and biological annotation of human chromosome 1.'Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.Bentley D.R.Nature 441:315-321(2006)
• Storage Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Target Info

• Gene Symbol: PSMB2
• Gene Full Name: proteasome 20S subunit beta 2
• Alias Symbols: HC7-I;macropain subunit C7-I;multicatalytic endopeptidase complex subunit C7-1;multicatalytic endopeptidase complex subunit C7-I;proteasome (prosome, macropain) subunit, beta type, 2;proteasome beta 2 subunit;proteasome component C7-I;proteasome subunit beta 2;proteasome subunit beta type-2;proteasome subunit beta4;proteasome subunit, beta type, 2;testicular tissue protein Li 152.
• NCBI Gene Id: 5690
• Protein Name: Proteasome subunit beta type-2
• Description of Target: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
• Uniprot ID: P49721