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Catalog No: OABF01738
Size:100UL
Price: $438.00
SKU
OABF01738
Availability: 3 to 5 business days.
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Datasheets/ManualsPrintable datasheet for RAB7A Antibody (OABF01738)
Product Info
Predicted Species ReactivityHuman|Mouse|Rat
Product FormatLiquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationELISA, ICC, IF, WB
Additional InformationSubcellular location:
Reconstitution and Storage-20°C
ImmunogenKLH conjugated synthetic peptide derived from human RAB7
PurificationProtein A Purified
Concentration1 ug/ul
Application InfoWB: 1:100 - 1000
IHC-P: : 1:100 - 500
Gene SymbolRAB7A
Gene Full NameRAB7A, member RAS oncogene family
Alias SymbolsCMT2B;PRO2706;RAB7;RAB7, member RAS oncogene family;Ras-associated protein RAB7;ras-related protein Rab-7a.
NCBI Gene Id7879
Protein NameRas-related protein Rab-7a
Description of TargetKey regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Uniprot IDP51149
  1. What is the species homology for "RAB7A Antibody (OABF01738)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".

  2. How long will it take to receive "RAB7A Antibody (OABF01738)"?

    This item is available "3 to 5 business days.".

  3. What buffer format is "RAB7A Antibody (OABF01738)" provided in?

    This item is provided in "Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "RAB7A Antibody (OABF01738)"?

    This target may also be called "CMT2B;PRO2706;RAB7;RAB7, member RAS oncogene family;Ras-associated protein RAB7;ras-related protein Rab-7a." in publications.

  5. What is the shipping cost for "RAB7A Antibody (OABF01738)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "RAB7A Antibody (OABF01738)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "RAB7A Antibody (OABF01738)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "RAB7A Antibody (OABF01738)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "RAB7A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "RAB7A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "RAB7A"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "RAB7A"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "RAB7A"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "RAB7A"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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