RAB5A Recombinant Protein (OPCD06570)

Catalog No: OPCD06570

RAB5A Recombinant Protein (OPCD06570) using SDS-PAGE

RAB5A Recombinant Protein (OPCD06570) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Met1-Ser214
  Isoelectric Point: 8.3
  Subcellular Location: Membrane, Cytoplasm
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 100 ug/mL (prior to lyoph)
• Purity: >97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: RAB5A
• Gene Full Name: RAB5A, member RAS oncogene family
• Alias Symbols: RAB5;RAS-associated protein RAB5A;ras-related protein Rab-5A.
• NCBI Gene Id: 5868
• Protein Name: Ras-related protein Rab-5A
• Description of Target: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).
• Uniprot ID: P20339
• Protein Accession #: NP_001278977.1
• Nucleotide Accession #: NM_001292048.1
• Protein Size (# AA): Met1~Ser214
• Molecular Weight: 31kDa