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RAB1A Recombinant Protein (OPCD00245)

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Predicted Species Reactivity:
Human
Product Format:
Lyophilized 100mM NaHCO3, 500mM NaCl (pH 8.3) containing 0.01% SKL and 5% Trehalose
Host:
E.coli
Conjugation:
Unconjugated
Application:
SDS-PAGE, WB, ELISA, IP
Additional Information:
Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
Isoelectric Point: 5.9
Subcellular Location: Golgi apparatus
:::
Residues: Ser2-Cys205
Reconstitution and Storage:
Reconstitute in PBS or others.
Store at 2-8C for one month. Aliquot and store at -80C for 12 months. Avoid repeated freeze/thaw cycles.
Gene Symbol:
RAB1A
Official Gene Full Name:
RAB1A, member RAS oncogene family
Alias Symbols:
DKFZp564B163, RAB1, Ras-related protein Rab-1A, YPT1, YPT1-related protein
NCBI Gene Id:
5861
Protein Name:
Ras-related protein Rab-1A
Description of Target:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.
Swissprot Id:
P62820
Protein Accession #:
NP_004152.1
Nucleotide Accession #:
NM_004161.4
Molecular Weight:
26 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express RAB1A.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express RAB1A.
Formulation:
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Purity:
>95%
Source:
Prokaryotic Expressed Recombinant
Tag:
N-terminal His Tag
Datasheets/Manuals:
Printable datasheet for OPCD00245

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