RAB1A Antibody - HRP Conjugated (OACA00187)

Catalog No: OACA00187

Size:100ug

All lanes : Ras-related protein Rab-1A antibody at at 2 µg/ml
Lane 1 :EC109 whole cell lysate
Lane 2 :293T whole cell lysate
Secondary Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size : 22.5 kDa
Observed band size: 80kDa

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: HRP
• Application: Enzyme-linked immunosorbent assay
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Ras-related protein Rab-1A protein (2-205AA)
• Purification: Protein G Purified
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Reference: [1] Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A.'Farnsworth C.C., Seabra M.C., Ericsson L.H., Gelb M.H., Glomset J.A.Proc. Natl. Acad. Sci. U.S.A. 91:11963-11967(1994)
  [2] Initial characterization of the human central proteome.'Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011)
  [3] Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2.'Bailly E., McCaffrey M., Touchot N., Zahraoui A., Goud B., Bornens M.
• Storage Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Target Info

• Gene Symbol: RAB1A
• Gene Full Name: RAB1A, member RAS oncogene family
• Alias Symbols: GTP binding protein Rab1a;Rab GTPase YPT1 homolog;RAB1;RAB1, member RAS oncogene family;ras-related protein Rab-1A;YPT1;YPT1-related protein.
• NCBI Gene Id: 5861
• Protein Name: Ras-related protein Rab-1A
• Description of Target: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.
• Uniprot ID: P62820
• Protein Accession #: NP_004152.1; NP_056358.1
• Nucleotide Accession #: NM_004161.4; NM_015543.1