PVRL3 Antibody (OAAF04021)

Catalog No: OAAF04021 (Formerly GWB-ASE842)

Size:100 ug

Western blot analysis of extracts from A549 cells, using PVRL3 Antibody. The lane on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human PVRL3.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: PVRL3 antibody detects endogenous levels of total PVRL3 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB: 1:500~1:3000; ELISA: 1:1000
• Reference: Reymond N., Gene 255:347-355(2000).
  Mueller S., J. Biol. Chem. 278-31251-31260(2003).
  Fujito T., J. Cell Biol. 171:165-173(2005).

Target Info

• Gene Symbol: NECTIN3
• Gene Full Name: nectin cell adhesion molecule 3
• Alias Symbols: CD113;CDW113;nectin 3;Nectin cell adhesion molecule 3;nectin-3;poliovirus receptor-related 3;poliovirus receptor-related protein 3;PPR3;PRR3;PVRL3;PVRR3.
• NCBI Gene Id: 25945
• Protein Name: Nectin-3
• Description of Target: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.
• Uniprot ID: Q9NQS3
• Protein Accession #: NP_001230215.1
• Molecular Weight: 61 kDa