PURA Antibody - N-terminal region (ARP33201_P050)

Catalog No: ARP33201_P050

Host: Rabbit
Target Name: PURA
Sample Tissue: Human THP-1 Whole Cell lysates
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PURA
• Purification: Affinity purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%
• Peptide Sequence: Synthetic peptide located within the following region: MADRDSGSEQGGAALGSGGSLGHPGSGSGSGGGGGGGGGGGGSGGGGGGA
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-PURA (ARP33201_P050) antibody is Catalog # AAP33201
• Reference: Wang,L.G., (2008) Cancer Res. 68 (8), 2678-2688

Target Info

• Gene Symbol: PURA
• Gene Full Name: purine rich element binding protein A
• Alias Symbols: PUR1, MRD31, PURALPHA, PUR-ALPHA
• NCBI Gene Id: 5813
• Protein Name: Transcriptional activator protein Pur-alpha
• Description of Target: This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
• Uniprot ID: Q00577
• Protein Accession #: NP_005850
• Nucleotide Accession #: NM_005859.4
• Protein Size (# AA): 322
• Molecular Weight: 35 kDa
• Protein Interactions: RAF1; UBC; LIN28B; LIN28A; BMI1; TARDBP; IGSF8; ICAM1; IL7R; ZNF638; DDX23; RFC3; RFC2; RB1; PURB; POLA1; CAND1; CUL1; CUL3; EIF2AK2; POU5F1; MEPCE; HNRNPA1; ADAP1; CCNT1; E2F1; SP1; YBX1; CDK5; CNBP; Jvgp5;