PTPRN2 Recombinant Protein (OPCD00153)

Catalog No: OPCD00153

PTPRN2 Recombinant Protein (OPCD00153) using SDS-PAGE

PTPRN2 Recombinant Protein (OPCD00153) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Gly782-Gln1001
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Ptprn2
• Gene Full Name: protein tyrosine phosphatase, receptor type, N polypeptide 2
• Alias Symbols: 4930425H11Rik;IA-2 beta;IA-2b;IA2beta;mKIAA0387;ph;phogrin;Phol;protein tyrosine phosphatase-NP;PT;PTP IA-2beta;PTP-NP;receptor-type tyrosine-protein phosphatase N2;R-PTP-N2.
• NCBI Gene Id: 19276
• Protein Name: Receptor-type tyrosine-protein phosphatase N2
• Description of Target: Plays a role in vesicle-mediated secretory processes (PubMed:21732083). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:21732083). Plays a role in insulin secretion in response to glucose stimuli (PubMed:15220191, PubMed:16418280, PubMed:21732083). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (PubMed:16269463). Required to maintain normal levels of renin expression and renin release (PubMed:19019914). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (PubMed:12364328). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate (PI(4,5)P2), phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (By similarity). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolyzation of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (By similarity).
• Uniprot ID: P80560
• Protein Accession #: NP_035345.2
• Nucleotide Accession #: NM_011215.2
• Protein Size (# AA): Gly782~Gln1001
• Molecular Weight: 29kDa