PTPRN Recombinant Protein (OPCD06527)

Catalog No: OPCD06527

PTPRN Recombinant Protein (OPCD06527) using SDS-PAGE

PTPRN Recombinant Protein (OPCD06527) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Pro368-Ala575
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: PTPRN
• Gene Full Name: protein tyrosine phosphatase receptor type N
• Alias Symbols: IA2;IA-2;IA-2/PTP;ICA 512;ICA512;insulinoma-associated tyrosine-phosphatase-like protein;islet cell antigen 2;islet cell antigen 512;islet cell autoantigen 3;protein tyrosine phosphatase-like N;PTP IA-2;receptor-type tyrosine-protein phosphatase-like N;R-PTP-N.
• NCBI Gene Id: 5798
• Protein Name: Receptor-type tyrosine-protein phosphatase-like N
• Description of Target: Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity).
• Uniprot ID: Q16849
• Protein Accession #: NP_001186692.1
• Nucleotide Accession #: NM_001199763.1
• Protein Size (# AA): Leu185~Leu367
• Molecular Weight: 23kDa