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PTPRC Recombinant Protein (OPCD06515)

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Predicted Species Reactivity:
Human
Product Format:
Lyophilized
Host:
E.coli
Conjugation:
Unconjugated
Application:
SDS-PAGE, WB, ELISA, IP
Additional Information:
Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
:::
Residues: Asp193-Lys575
:::
Subcellular Location: Membrane; Single-pass type I membrane protein. Membrane raf
Reconstitution and Storage:
Reconstitute in PBS or others.
Store at 2-8C for one month. Aliquot and store at -80C for 12 months. Avoid repeated freeze/thaw cycles.
Gene Symbol:
PTPRC
Official Gene Full Name:
protein tyrosine phosphatase, receptor type C
Alias Symbols:
B220, CD45, CD45R, GP180, LCA, L-CA, Leukocyte common antigen, LY5, Receptor-type tyrosine-protein phosphatase C, T200
NCBI Gene Id:
5788
Protein Name:
Receptor-type tyrosine-protein phosphatase C
Description of Target:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.
Swissprot Id:
P08575
Protein Accession #:
NP_002829.3
Nucleotide Accession #:
NM_002838.4
Molecular Weight:
45 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express PTPRC.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express PTPRC.
Formulation:
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Purity:
> 95%
Source:
Prokaryotic Expressed Recombinant
Tag:
N-terminal His Tag
Datasheets/Manuals:
Printable datasheet for OPCD06515

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