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Catalog No: OATA00431
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OATA00431
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Datasheets/ManualsPrintable datasheet for OATA00431
Product Info
Tested Species ReactivityHuman, Mouse
Predicted Species ReactivityFeline
Product FormatLiquid. 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2
ClonalityMonoclonal
CloneRA3-6B2
IsotypeRat IgG2a, kappa
HostRat
ConjugationPE: Phycoerythrin, CY7: Cyanine 7
ApplicationFC
::Excitation Laser: Blue (488 nm), Green (532 nm), Yellow-Green (561 nm)
::Emmision: 785 nm
Reconstitution and Storage2-8C protected from light
SpecificityCD45R (B220)
Application InfoThis antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indicated). Please refer to the figure legend for the optimal concentration used to stain the tissue shown. We recommend titrating the antibody under your specific conditions to determine the optimal concentration of antibody needed in your experimental system.
Reference

Willinger T and Flavell RA. 2012. Proc. Natl. Acad. Sci. 109:8670-8675. (Flow cytometry)

Meredith MM, Liu K, Darrasse-Jeze G, Kamphorst AO, Schreiber HA, Guermonprez P, Idoyaga J, Cheong C, Yao K-H, Niec RE, and Nussenzweig MC. 2012. J. Exp. Med. 209: 1153-1165. (Immunofluorescence microscopy: acetone-fixed frozen tissue)

Becker-Herman A, Meyer-Bahlburg A, Schwartz MA, Jackson SW, Hudkins KL, Liu C, Sather BD, Khim S, Liggitt D, Song W, Silverman GJ, Alpers CE and Rawlings DJ. 2011. J. Exp. Med. 208:2033-2042. (Immunofluorescence microscopy - OCT embedded frozen tissue)

Bertossi A, Aichinger M, Sansonetti P, Lech , Neff F, Pal M, Wunderlich FT, Anders H, Klein L, and Schmidt-Supprian M. 2011. J. Exp. Med. 208:1749-1756. (Immunofluorescence microscopy)

De Clercq S, Gembarska A, Denecker G, Maetens M, Naessens M, Haigh K, Haigh JJ, and Marine J-C. 2010. Mol. Cell. Biol. 30:5394-5405. (Western Blot)

Nutt SL, Metcalf D, D"™Amico A, Polli M, and Wu L. 2005. J. Exp. Med. 201:221-231. (Immunomagnetic bead depletion)

Cappione AJ, Pugh-Bernard AE, Anolik JH, and Sanz I. 2004. J. Immunol. 172: 4298-4307. (Immunoprecipitation)

Monteith CE, Chelack BJ, Davis WC, and Haines DM. 1996. Can. J. Vet. Res. 60(3): 193-198. (Immunohistochemistry - feline tissue)

Whiteland JL, Nicholls SM, Shimeld C, Easty DL, Williams NA, and Hill TJ. 1995. J. Histochem. Cytochem. 43:313-320. (Immunohistochemistry - frozen tissue, paraffin embedded tissue)

Domiati-Saad R, Ogle EW, and Justement LB. 1993. J. Immunol. 151: 5936-5947. (in vivo blocking)

Gene SymbolPTPRC, PTPRC
Gene Full Nameprotein tyrosine phosphatase receptor type C
Alias SymbolsLy-, loc, B220, Cd45, L-CA, Ly-5, Lyt-, T200, CD45R, Lyt-4
NCBI Gene Id19264; 5788
Protein Namereceptor-type tyrosine-protein phosphatase C
Description of TargetThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Uniprot IDP08575, P06800
Protein Accession #NP_002829.3
Nucleotide Accession #NM_002838.4
  1. What is the species homology for "PTPRC/PTPRC Antibody : PE-Cy7 (OATA00431)"?

    The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Feline".

  2. How long will it take to receive "PTPRC/PTPRC Antibody : PE-Cy7 (OATA00431)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "PTPRC/PTPRC Antibody : PE-Cy7 (OATA00431)" provided in?

    This item is provided in "Liquid. 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "PTPRC/PTPRC Antibody : PE-Cy7 (OATA00431)"?

    This target may also be called "Ly-, loc, B220, Cd45, L-CA, Ly-5, Lyt-, T200, CD45R, Lyt-4" in publications.

  5. What is the shipping cost for "PTPRC/PTPRC Antibody : PE-Cy7 (OATA00431)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "PTPRC/PTPRC Antibody : PE-Cy7 (OATA00431)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "PTPRC/PTPRC Antibody : PE-Cy7 (OATA00431)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "PTPRC/PTPRC Antibody : PE-Cy7 (OATA00431)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "PTPRC, PTPRC"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "PTPRC, PTPRC"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "PTPRC, PTPRC"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "PTPRC, PTPRC"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "PTPRC, PTPRC"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "PTPRC, PTPRC"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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