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PTPRC Antibody : Biotin (OATA00160)

100 ug
$94.00
In Stock
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Tested Species Reactivity:
Human
Predicted Species Reactivity:
Chimpanzee
Product Format:
Liquid. 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, pH 7.2
Clonality:
Monoclonal
Clone:
UCHL1
Isotype:
Mouse IgG2a, kappa
Host:
Mouse
Conjugation:
Biotin
Application:
FC, IHC-F, IHC-P, IF, IP, WB
Reconstitution and Storage:
2-8C protected from light
Gene Symbol:
PTPRC
NCBI Gene Id:
5788
Official Gene Full Name:
protein tyrosine phosphatase receptor type C
Protein Name:
receptor-type tyrosine-protein phosphatase C
Swissprot Id:
P08575
Protein Accession #:
NP_002829.3
Nucleotide Accession #:
NM_002838.4
Alias Symbols:
LCA, LY5, B220, CD45, L-CA, T200, CD45R, GP180
Description of Target:
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express PTPRC.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express PTPRC.
Datasheets/Manuals:
Printable datasheet for OATA00160
Specificity:
CD45RO
Application Info:
This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indicated). Please refer to the figure legend for the optimal concentration used to stain the tissue shown. We recommend titrating the antibody under your specific conditions to determine the optimal concentration of antibody needed in your experimental system.
Target Reference:

Imanguli MM, Swaim WD, League SC, Gress RE, Pavletic SZ, and Hakim FT. 2009. Blood. 113: 3620-3630. (Immunohistochemistry - paraffin embedded tissue)

Di Carlo E, D"™Antuono T, Pompa P, Giuliani R, Rosini S, Stuppia L, Musiani P, and Sorrentino C. 2009. Clin. Cancer Res. 15: 2979-2987. (Immunohistochemistry - paraffin embedded tissue)

Kap YS, van Meurs M, van Driel N, Koopman G, Melief M-J, Brok HPM, Laman JD, and "˜t Hart BA. 2009. J.Histochemistry & Cytochemistry. 57: 1159-1167. (Immunohistochemistry - Chimpanzee frozen tissue)

Bonzheim I, Geissinger E, Tinguely M, Roth S, Grieb T, Reimer P, Wilhelm M, Rosenwald A, Muller-Hermelink HK, and Rudiger T. 2008. Am. J. Clin. Pathol. 130: 613-619. (Immunofluorescence microscopy - frozen tissue)

Kim M-H, Suh H-S, Si Q, Terman BE, and Lee SC. 2006. J. Virol. 80: 62-72. (Western Blot)

Cappione AJ, Pugh-Bernard AE, Anolik JH, and Sanz I. 2004. J. Immunol. 172: 4298-4307. (Immunoprecipitation)

Gougeon ML, Lecoeur H, Boudet F, Ledru E. Marzabal S, Boullier S, Roue R, Nagata S, and Heeney J. 1997. J. Immunol. 158: 2964-2976. (Flow cytometry - Chimpanzee)

Kulas DT, Freund GG, and Mooney RA. 1996. J. Biol. Chem. 271: 755-760. (Immunoprecipitation, Western Blot)

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