Catalog No: OPCD06509
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OPCD06509
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Datasheets/ManualsPrintable datasheet for PTN Recombinant Protein (OPCD06509)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Gly33-Asp168
::Subcellular Location: Secreted
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolPTN
Gene Full Namepleiotrophin
Alias SymbolsHARP;HBBM;HB-GAM;HBGF8;HBGF-8;HBNF;HBNF-1;heparin affin regulatory protein;heparin-binding brain mitogen;heparin-binding growth factor 8;heparin-binding growth-associated molecule;heparin-binding neurite outgrowth promoting factor;heparin-binding neurite outgrowth-promoting factor 1;NEGF1;OSF-1;osteoblast-specific factor 1;pleiotrophin;pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1).
NCBI Gene Id5764
Protein NamePleiotrophin
Description of TargetSecreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).
Uniprot IDP21246
Protein Accession #NP_001308315.1
Nucleotide Accession #NM_001321386.1
Protein Size (# AA)Gly33~Asp168
Molecular Weight19kDa
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