PTK7 Antibody (OAPB00560)

Catalog No: OAPB00560

Size:100UG

Western blot analysis of PTK7 in (A) human, (B) mouse and (C) rat colon tissue lysate with PTK7 antibody at 1 ug/mL.

Immunohistochemistry of PTK7 in human colon tissue with PTK7 antibody at 5 ug/mL.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid. PTK7 Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry-Paraffin|Western blot
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: PTK7 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: PTK7 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human PTK7. The immunogen is located within amino acids 250 - 300 of PTK7.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-PTK7 antibody is Catalog # OEPB02691
• Application Info: PTK7 antibody can be used for detection of PTK7 by Western blot at 0.5 - 1 ug/ml. (Optimal dilution should be determined by user)
• Reference: Park SK, Lee HS and Lee ST. Characterization of the human full-length PTK7 cDNA encoding a receptor protein kinase-like molecule closely related to chick KLG. J. Biochem.1996; 119:235-9.;Lu X, Borchers AG, Jolicoeur C, et al. PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature2004; 430:93-8.;Easty DJ, Mitchell PJ, Patel K, et al. Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma. Int. J. Cancer1997; 1061-5.;Muller-Tidow C, Schwable J, Steffen B, et al. High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets. Clin. Cancer Res.2004; 10:1241-9.

Target Info

• Gene Symbol: PTK7
• Gene Full Name: protein tyrosine kinase 7 (inactive)
• Alias Symbols: CCK4;CCK-4;colon carcinoma kinase 4;inactive tyrosine-protein kinase 7;Protein-tyrosine kinase 7;pseudo tyrosine kinase receptor 7;PTK7 protein tyrosine kinase 7;tyrosine-protein kinase-like 7.
• NCBI Gene Id: 5754
• Protein Name: Inactive tyrosine-protein kinase 7|PTK7 protein tyrosine kinase 7 [Homo sapiens]
• Description of Target: Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
• Uniprot ID: Q13308
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/AAH71557