PTK6 Antibody (Phospho-Tyr447) (OASG00830)

Catalog No: OASG00830

Size:100 uL

Western Blot using 293

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IF
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human Brk around the phosphorylation site of Y447. Location: 390-470aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Tyr447
• Specificity: Phospho-Brk (Tyr447) Polyclonal Antibody detects endogenous levels of Brk protein only when phosphorylated at Y447.
• Application Info: WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000;

Target Info

• Gene Symbol: PTK6
• Gene Full Name: protein tyrosine kinase 6
• Alias Symbols: BRK
• NCBI Gene Id: 5753;
• Description of Target: The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants.
• Uniprot ID: Q13882
• Molecular Weight: 50 kDa