PTK2 Antibody - Biotin Conjugated (OACA01990)

Catalog No: OACA01990

Size:100ug

Product Info

• Predicted Species Reactivity: Chicken
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Biotin
• Application: Enzyme-linked immunosorbent assay
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Chicken Focal adhesion kinase 1 protein (376-683AA)
• Purification: Protein G Purified
• Purity: Caprylic Acid Ammonium Sulfate Precipitation purified
• Reference: [1] pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.'Schaller M.D., Borgman C.A., Cobb B.S., Vines R.R., Reynolds A.B., Parsons J.T.Proc. Natl. Acad. Sci. U.S.A. 89:5192-5196(1992)
  [2] Chicken and mouse focal adhesion kinases are similar in structure at their amino termini.'Devor B.B., Zhang X., Patel S.K., Polte T.R., Hanks S.K.Biochem. Biophys. Res. Commun. 190:1084-1089(1993)
  [3] Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK.'Schaller M.D., Borgman C.A., Parsons J.T.Mol. Cell. Biol. 13:785-791(1993)
• Storage Buffer: Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Target Info

• Gene Symbol: PTK2
• Gene Full Name: protein tyrosine kinase 2
• Alias Symbols: FADK 1;FAK;focal adhesion kinase 1;focal adhesion kinase-related nonkinase;FRNK;p125FAK;p41/p43FRNK;pp125FAK;Protein-tyrosine kinase 2;PTK2 protein tyrosine kinase 2.
• NCBI Gene Id: 396416
• Protein Name: Focal adhesion kinase 1
• Description of Target: Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development, embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), ephrin receptors, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Regulates P53/TP53 activity and stability. Phosphorylates SRC; this increases SRC kinase activity. Isoform 2 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling.
• Uniprot ID: Q00944
• Protein Accession #: NP_001186578.1; NP_722560.1
• Nucleotide Accession #: NM_001199649.1; NM_153831.3