Catalog No: OPCD06499
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OPCD06499
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PTHLH Recombinant Protein (OPCD06499)

Datasheets/ManualsPrintable datasheet for PTHLH Recombinant Protein (OPCD06499)
Product Info
Predicted Species ReactivityRat|Rattus norvegicus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Ala37-His177
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolPthlh
Gene Full Nameparathyroid hormone-like hormone
Alias Symbolsparathyroid hormone-like peptide;parathyroid hormone-like protein;parathyroid hormone-related protein;parathyroid-like peptide;PLP;PTHrP;PTH-rP.
NCBI Gene Id24695
Protein NameParathyroid hormone-related protein
Description of TargetNeuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teethRequired for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity).
Uniprot IDP13085
Protein Accession #NP_036768.1
Nucleotide Accession #NM_012636.1
Protein Size (# AA)Ala37~His177
Molecular Weight27/33kDa
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