PTHLH Recombinant Protein (OPCD06496)

Catalog No: OPCD06496

PTHLH Recombinant Protein (OPCD06496) using SDS-PAGE

PTHLH Recombinant Protein (OPCD06496) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ala37-His175
  Subcellular Location: Nucleus, Secreted, Cytoplasm
  Isoelectric Point: 10.1
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 50 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: PTHLH
• Alias Symbols: Parathyroid hormone-like protein.
• Protein Name: Parathyroid hormone-related protein
• Description of Target: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
• Uniprot ID: P22858
• Protein Size (# AA): Ala37~His175
• Molecular Weight: 18/19kDa