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Datasheets/Manuals | Printable datasheet for PTGES2 Antibody (OAED00003) (OAED00003) |
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Predicted Species Reactivity | Non-species Specific |
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Product Format | Liquid. PBS containing bovine gamma globulin and 0.1% sodium azide. |
Clonality | Polyclonal |
Host | Rabbit |
Application | Enzyme-linked immunosorbent assay|Radioimmunoassay |
Reconstitution and Storage | Long Term Storage : -20C |
Immunogen | Prostaglandin E2. |
Specificity | Species independent. |
Reference | Inhibition of lipopolysaccharide-induced prostaglandin E(2) production and inflammation by the Na(+)/H(+) exchanger inhibitors: N. Hirasawa, et al. ; J. Pharmacol. Exp. Ther. 321, 345 (2007), Application(s): RIA using mouse culture supernatants, Abstract; Molecular Characterization of Canine Prostaglandin G/H Synthase-2 and Regulation in Prostatic Adenocarcinoma Cells in Vitro: D. Boutemmine, et al. ; Endocrinology 143, 1134 (2002), Application(s): RIA using canine cell lysates, Abstract; Highly Unsaturated (n-3) Fatty Acids, but Not {alpha}-Linolenic, Conjugated Linoleic or {gamma}-Linolenic Acids, Reduce Tumorigenesis in ApcMin/+ Mice: B.H. Petrik, et al. ; J. Nutr. 130, 2434 (2000), Application(s): RIA using mouse cell lysates, Abstract; Down-Regulation of Oxytocin-Induced Cyclooxygenase-2 and Prostaglandin F Synthase Expression by Interferon-{tau} in Bovine Endometrial Cells: C.W. Xiao, et al. ; Biol. Reprod. 60, 656 (1999), Application(s): RIA using bovine cell lysates, Abstract; 14,15-Epoxyeicosatrienoic acid inhibits prostaglandin E2 production in vascular smooth muscle cells: X. Fang, et al. ; Am. J. Physiol. Heart Circ. Physiol. 275, H2113 (1998), Application(s): RIA using porcine cell lysates, Abstract; |
Gene Symbol | PTGES2 |
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Gene Full Name | Prostaglandin E synthase 2 |
Alias Symbols | GBF1, GBF-1, PGES2, C9orf15, mPGES-2 |
NCBI Gene Id | 80142 |
Protein Name | Prostaglandin E synthase 2 |
Description of Target | Prostaglandin E2 (PGE2) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis. Oxidation of arachidonic acid by prostaglandin synthases (COX-1 and COX-2) produces prostaglandin H2 (PGH2), which is further metabolized by PGE synthases into its major product, PGE2. PGE2 mediates autocrine and paracrine signaling by binding to G-protein coupled receptors (EP1, EP2, EP3, EP4) on the cell surface, functioning to modulate phospholipase C and adenylate cyclase activity. PGE2 has been of great interest as a therapeutic target, either by modulation of its synthesis by COX inhibitors (NSAIDS) or by modulation of its receptors by downregulation or binding antagonists. PGE2 production in a variety of tissues has been shown to modulate numerous physiological processes including natriuresis in the kidney, smooth muscle elasticity in the vasculature, and the inflammatory response to damaged tissues by monocytes and macrophages. |
Uniprot ID | Q9H7Z7 |
Protein Accession # | NP_001243264.1; NP_079348.1; NP_945176.1 |
Nucleotide Accession # | NM_001256335.1; NM_025072.6; NM_198938.2 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "PTGES2 Antibody (OAED00003)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Non-species Specific".
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How long will it take to receive "PTGES2 Antibody (OAED00003)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 week".
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What buffer format is "PTGES2 Antibody (OAED00003)" provided in?
This item is provided in "Liquid. PBS containing bovine gamma globulin and 0.1% sodium azide.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "PTGES2 Antibody (OAED00003)"?
This target may also be called "GBF1, GBF-1, PGES2, C9orf15, mPGES-2" in publications.
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What is the shipping cost for "PTGES2 Antibody (OAED00003)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "PTGES2 Antibody (OAED00003)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "PTGES2 Antibody (OAED00003)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "PTGES2 Antibody (OAED00003)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "PTGES2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "PTGES2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "PTGES2"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "PTGES2"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "PTGES2"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "PTGES2"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.