PTGDS Recombinant Protein (OPCD06141)

Catalog No: OPCD06141

PTGDS Recombinant Protein (OPCD06141) using SDS-PAGE

PTGDS Recombinant Protein (OPCD06141) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Pro32-Gln190
  Subcellular Location: Rough endoplasmic reticulum. Nucleus membrane. Golgi apparatus. Cytoplasm, perinuclear region. Secreted.
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: PTGDS
• Gene Full Name: prostaglandin D2 synthase
• Alias Symbols: beta-trace protein;cerebrin-28;glutathione-independent PGD synthase;glutathione-independent PGD synthetase;lipocalin-type prostaglandin D synthase;Lipocalin-type prostaglandin-D synthase;LPGDS;L-PGDS;PDS;PGD2;PGD2 synthase;PGDS;PGDS2;prostaglandin D synthase;prostaglandin D2 synthase 21kDa (brain);Prostaglandin-D2 synthase;prostaglandin-H2 D-isomerase;testis tissue sperm-binding protein Li 63n.
• NCBI Gene Id: 5730
• Protein Name: Prostaglandin-H2 D-isomerase
• Description of Target: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
• Uniprot ID: P41222
• Protein Accession #: NP_000945.3
• Nucleotide Accession #: NM_000954.5
• Protein Size (# AA): Pro32~Gln190
• Molecular Weight: 22kDa