Size:100 ul
$220.00
Discontinued
SKU
OAAH00020
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More Information
Predicted Species Reactivity Human, Mouse, Rat, Monkey, Chinese hamster, Dog
Clonality Monoclonal
Isotype Mouse IgG2b
Host Mouse
Reconstitution and Storage Store the product at -20C. Stable for one year from the date of shipment.
Immunogen This Aviva monoclonal antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to carboxy-terminal residues of human PTEN.
Datasheets/Manuals Printable datasheet for PTEN (30G12) Mouse mAb (OAAH00020) OAAH00020
Specificity PTEN (30G12) Mouse mAb detects endogenous levels of total PTEN protein.
Source Mouse mAb
Application Info WB: 1:2000
IF: 1:200
IHC: 1:200
Target Reference 1. Bigner, S.H., et al. 1988. Specific chromosomal abnormalities in malignant
human gliomas. Cancer Res. 48: 405-411.
2. Li, J., et al. 1997. PTEN, a putative protein tyrosine phosphatase gene
mutated in human brain, breast, and prostate cancer. Science 275: 1943-
1947.
3. Fumari, F.B., et al. 1997. Growth suppression of glioma cells by PTEN
requires a functional phosphatase catalytic domain. Proc. Natl. Acad. Sci.
USA 94: 12479-12484.
Gene Symbol Pten
Alias Symbols TEP1, MMAC1, AI463227, 2310035O07Rik, A130070J02Rik, B430203M17Rik,
NCBI Gene Id 19211
Protein Name Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Description of Target As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10q23. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN gene, also designated MMAC1 (for mutated in multiple advanced cancers) and TEP1. This candidate tumor suppressor gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. PTEN has been associated with Cowden disease, an autosomal dominant cancer predisposition syndrome. The PTEN gene product is a putative protein tyrosine phosphatase that is localized to the cytoplasm, and it shares extensive homology with the cytoskeletal proteins tensin and auxilin. Gene transfer studies have indicated that the phosphatase domain of PTEN is essential for growth suppression of glioma cells.
Swissprot Id O08586
Molecular Weight 55 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express Pten.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express Pten.
  1. What is the species homology for "PTEN (30G12) Mouse mAb (OAAH00020)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat, Monkey, Chinese hamster, Dog".

  2. How long will it take to receive "PTEN (30G12) Mouse mAb (OAAH00020)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "PTEN (30G12) Mouse mAb (OAAH00020)" provided in?

    This item is provided in "".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "PTEN (30G12) Mouse mAb (OAAH00020)"?

    This target may also be called "TEP1, MMAC1, AI463227, 2310035O07Rik, A130070J02Rik, B430203M17Rik, " in publications.

  5. What is the shipping cost for "PTEN (30G12) Mouse mAb (OAAH00020)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "PTEN (30G12) Mouse mAb (OAAH00020)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "PTEN (30G12) Mouse mAb (OAAH00020)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "55 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "PTEN (30G12) Mouse mAb (OAAH00020)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "PTEN"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "PTEN"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "PTEN"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "PTEN"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "PTEN"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "PTEN"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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