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PTEN (30G12) Mouse mAb (OAAH00020)

  • Catalog#: OAAH00020
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Gene Symbol:
Pten
NCBI Gene Id:
19211
Protein Name:
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Swissprot Id:
O08586
Alias Symbols:
TEP1, MMAC1, AI463227, 2310035O07Rik, A130070J02Rik, B430203M17Rik,
Description of Target:
As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10q23. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN gene, also designated MMAC1 (for mutated in multiple advanced cancers) and TEP1. This candidate tumor suppressor gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. PTEN has been associated with Cowden disease, an autosomal dominant cancer predisposition syndrome. The PTEN gene product is a putative protein tyrosine phosphatase that is localized to the cytoplasm, and it shares extensive homology with the cytoskeletal proteins tensin and auxilin. Gene transfer studies have indicated that the phosphatase domain of PTEN is essential for growth suppression of glioma cells.
Molecular Weight:
55 kDa
Host:
Mouse
Clonality:
Monoclonal
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express Pten.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express Pten.
Immunogen:
This Aviva monoclonal antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to carboxy-terminal residues of human PTEN.
Predicted Species Reactivity:
Human, Mouse, Rat, Monkey, Chinese hamster, Dog
Reconstitution and Storage:
Store the product at -20C. Stable for one year from the date of shipment.
Datasheets/Manuals:
Printable datasheet for PTEN (30G12) Mouse mAb (OAAH00020) OAAH00020
Specificity:
PTEN (30G12) Mouse mAb detects endogenous levels of total PTEN protein.
Source:
Mouse mAb
Isotype:
Mouse IgG2b
Application Info:
WB: 1:2000
IF: 1:200
IHC: 1:200
Target Reference:
1. Bigner, S.H., et al. 1988. Specific chromosomal abnormalities in malignant
human gliomas. Cancer Res. 48: 405-411.
2. Li, J., et al. 1997. PTEN, a putative protein tyrosine phosphatase gene
mutated in human brain, breast, and prostate cancer. Science 275: 1943-
1947.
3. Fumari, F.B., et al. 1997. Growth suppression of glioma cells by PTEN
requires a functional phosphatase catalytic domain. Proc. Natl. Acad. Sci.
USA 94: 12479-12484.

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