PSMC3 Antibody (OAAF03090)

Catalog No: OAAF03090 (Formerly GWB-ASE227)

Size:100 ug

Western blot analysis of extracts from K562/HT-29 cells, using PRS6A Antibody. The lane on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid PBS (without Mg²⁺ and Ca²⁺) (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human PRS6A.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Specificity: PRS6A antibody detects endogenous levels of total PRS6A protein.
• Application Info: WB: 1:500~1000
  ELISA: 1:40000
• Reference: Leung D.W., Front. Biosci. 6:D944-D953(2001).
  Nagamine K., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
  Clark H.F., Genome Res. 13:2265-2270(2003).

Target Info

• Gene Symbol: PSMC3
• Gene Full Name: proteasome 26S subunit, ATPase 3
• Alias Symbols: 26S protease regulatory subunit 6A;26S proteasome AAA-ATPase subunit RPT5;26S proteasome regulatory subunit 6A;DCIDP;human immunodeficiency virus tat transactivator binding protein-1;proteasome (prosome, macropain) 26S subunit, ATPase, 3;Proteasome 26S subunit ATPase 3;proteasome subunit P50;RPT5;Tat-binding protein 1;TBP1;testicular secretory protein Li 42.
• NCBI Gene Id: 5702
• Protein Name: 26S proteasome regulatory subunit 6A
• Description of Target: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
• Uniprot ID: P17980
• Protein Accession #: NP_002795.2
• Molecular Weight: 49 kDa