Now Offering Over 102,157 Antibodies & 44,722 Antigens!

PSMA1 antibody - C-terminal region (ARP40417_P050)

100 ul
$289.00
In Stock

Conjugation Options

ARP40417_P050-FITC Conjugated

ARP40417_P050-HRP Conjugated

ARP40417_P050-Biotin Conjugated

Gene Symbol:
PSMA1
NCBI Gene Id:
5682
Official Gene Full Name:
Proteasome (prosome, macropain) subunit, alpha type, 1
Protein Name:
Proteasome subunit alpha type-1
Swissprot Id:
P25786
Protein Accession #:
NP_002777
Nucleotide Accession #:
NM_002786
Alias Symbols:
HC2, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915, NU, PROS30
Replacement Item:
This antibody may replace item sc-112756 from Santa Cruz Biotechnology.
Description of Target:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA1 is a member of the peptidase T1A family which is a 20S core alpha subunit.The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.
Protein Size (# AA):
263
Molecular Weight:
29kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express PSMA1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express PSMA1.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human PSMA1
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Complete computational species homology data:
Anti-PSMA1 (ARP40417_P050)
Peptide Sequence:
Synthetic peptide located within the following region: TYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDL
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
PRDM14; CEP70; CCDC102B; GNPTAB; CEP72; KCTD9; ROPN1; ABI3; SH3GLB1; APIP; LDOC1; MTUS2; MAPRE3; MAPRE1; IKZF3; MID2; EHMT2; PNMA2; IKZF1; TRIM10; HUWE1; HOMER3; PNMA1; KRT38; BLZF1; MAD1L1; MKRN3; REL; PSMA3; MLH1; KRT31; KRT15; KRTAP5-9; GOLGA2; CDA; CC
Blocking Peptide:
For anti-PSMA1 (ARP40417_P050) antibody is Catalog # AAP40417 (Previous Catalog # AAPP23493)
Datasheets/Manuals:
Printable datasheet for anti-PSMA1 (ARP40417_P050) antibody
Sample Type Confirmation:

PSMA1 is strongly supported by BioGPS gene expression data to be expressed in NCI460

Subunit:
alpha type-1
Target Reference:
Conticello,S.G., (2003) Curr. Biol. 13 (22), 2009-2013
Publications:

Cron, K. R. et al. Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. PLoS One 8, e73710 (2013). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 24040035

Tell us what you think about this item!

Write A Review
    Please, wait...