Catalog No: ARP58941_P050
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ARP58941_P050
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Datasheets/ManualsPrintable datasheet for anti-PSEN1 (ARP58941_P050) antibody
Product Info
Tested Species ReactivityHuman, Mouse
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIHC, IP, WB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human PSEN1
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 86%; Dog: 86%; Guinea Pig: 100%; Horse: 86%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 85%
Peptide SequenceSynthetic peptide located within the following region: EGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLG
Concentration0.5 mg/ml
Blocking PeptideFor anti-PSEN1 (ARP58941_P050) antibody is Catalog # AAP58941 (Previous Catalog # AAPP44888)
Sample Type Confirmation

PSEN1 is strongly supported by BioGPS gene expression data to be expressed in 721_B

Other Applications Image 1 DataIP Suggested Anti-PSEN1 Antibody
Positive Control: NT2 CELL/BRAIN TISSUE
Other Applications Image 2 DataIP Suggested Anti-PSEN1 antibody
Titration: 2 ug/ml
Positive Control: Mouse brain homogenate
Publications

Loss of endophilin-B1 exacerbates Alzheimer's disease pathology. Brain. 138, 2005-19 (2015). 25981964

Description
Gene SymbolPSEN1
Gene Full NamePresenilin 1
Alias SymbolsAD3, FAD, PS1, PS-1, S182, ACNINV3
NCBI Gene Id5663
Protein NamePresenilin-1
Description of TargetAlzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
Uniprot IDP49768
Protein Accession #NP_000012
Nucleotide Accession #NM_000021
Protein Size (# AA)467
Molecular Weight52 kDa
Protein InteractionsUBC; TRAF6; TGFBR1; ERLIN2; PSMB1; PSMA5; ETFA; TDP2; PSEN2; PSEN1; APH1B; PSENEN; APH1A; NCSTN; ITSN2; PDCD4; KANK2; EPB41L3; CDC37; TUBA1B; AP1M2; UMPS; PRDX2; ST13; SCN1A; RHEB; RAD23A; RAB3A; OXCT1; NOS3; NDUFS8; HMGB1; GCDH; GAPDH; FGF13; ENSA; DTNA;
  1. What is the species homology for "PSEN1 Antibody - middle region (ARP58941_P050)"?

    The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit".

  2. How long will it take to receive "PSEN1 Antibody - middle region (ARP58941_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "PSEN1 Antibody - middle region (ARP58941_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "PSEN1 Antibody - middle region (ARP58941_P050)"?

    This target may also be called "AD3, FAD, PS1, PS-1, S182, ACNINV3" in publications.

  5. What is the shipping cost for "PSEN1 Antibody - middle region (ARP58941_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "PSEN1 Antibody - middle region (ARP58941_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "PSEN1 Antibody - middle region (ARP58941_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "52 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "PSEN1 Antibody - middle region (ARP58941_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "PSEN1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "PSEN1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "PSEN1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "PSEN1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "PSEN1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "PSEN1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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