Transcription Regulation

Aviva Systems Biology manufactures over 3,000 antibodies for transcription factor research. These proteins have become an important tool for research associated with gene regulation. Transcription regulators control the rate and timing of gene transcription in a cell. A number of proteins govern this fundamental process by various mechanisms. Transcription factors can bind to promoter or enhancer regions of DNA and serve to promote or impede gene transcription. These bound transcription factors may be classified as activators or repressors. Activators aid in the recruitment of RNA polymerase to a given promoter region, thereby ‘activating’ the transcription process. The level of transcription may be enhanced by binding of proteins to specific regions of DNA known as enhancers. These regions are important in the control of gene expression levels, although they need not be near the target gene to function[1]. Repressors bind to areas of DNA (known as operators) that are close to promoters and act to block the function of RNA polymerase and thus inhibit the transcription process. The binding affinity of repressors can be altered by inducers, which promote transcription, and corepressors, which further repress transcription. Other proteins, such as Histone Deacetylases (HDACs), can modify the accessibility of DNA to transcriptional machinery and thus serve as regulators transcription regulators.

1. Spilianakis CG et al. 2005. Interchromosomal associations between alternatively expressed loci. Nature. Jun 2;435(7042):637-45.


Nucleotide sequences of a gene that are involved in the regulation of Transcription (The biosynthesis of RNA carried out on a template of DNA). They are involved in transcription as repressors or promoters. We have manufactured about 1800 antibody products for them.

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  1. Human THP-1 Whole Cell
    DDX11 Antibody - N-terminal region (ARP81919_P050)
    Catalog #: ARP81919_P050
    Protein Name: ATP-dependent DNA helicase DDX11
    Alias: CHL1, KRG2, WABS, CHLR1
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  2. Human HepG2 Whole Cell
    NUP133 Antibody - middle region (ARP75678_P050)
    Catalog #: ARP75678_P050
    Protein Name: Nuclear pore complex protein Nup133
    Alias: GAMOS8, NPHS18, hNUP133
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  3. Human PANC1 Whole Cell
    SMC5 Antibody - C-terminal region (ARP75443_P050)
    Catalog #: ARP75443_P050
    Protein Name: Structural maintenance of chromosomes protein 5
    Alias: SMC5L1
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  4. Mouse Lung
    MSL3 Antibody - middle region (ARP90784_P050)
    Catalog #: ARP90784_P050
    Protein Name: male-specific lethal 3 homolog
    Alias: Msl31, Msl3l1, AU018931
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  5. Mouse Testis
    INSM1 Antibody - middle region (ARP90761_P050)
    Catalog #: ARP90761_P050
    Protein Name: insulinoma-associated protein 1
    Alias: IA-1
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  6. Mouse Stomach
    PURB Antibody - C-terminal region (ARP90736_P050)
    Catalog #: ARP90736_P050
    Protein Name: transcriptional activator protein Pur-beta
    Alias: Cager-2, AA114818, D11Bwg0414e, 2310015K15Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  7. Mouse Brain
    PPP3CA Antibody - C-terminal region (ARP90315_P050)
    Catalog #: ARP90315_P050
    Protein Name: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
    Alias: CN, CnA, Caln, Calna, 2900074D19Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  8. Mouse Liver
    THRA Antibody - N-terminal region (ARP89619_P050)
    Catalog #: ARP89619_P050
    Protein Name: thyroid hormone receptor alpha
    Alias: Rvr, Erba, Nr1a1, Thra1, Thra2, T3R[a], AW259572, T3Ralpha, c-erbA-1, c-erbAalpha, c-erbA-alpha, 6430529J03Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  9. Mouse Thymus
    CITED2 Antibody - middle region (ARP89613_P050)
    Catalog #: ARP89613_P050
    Protein Name: cbp/p300-interacting transactivator 2
    Alias: Mrg1, Msg2, p35srj, AI835299, ER154-like
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
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