Transcription Factor

Transcription factors are proteins that regulate gene expression by binding to DNA via one or more DNA-binding domains. This binding is achieved via a combination of electrostatic and van der waals forces and can occur at many closely-related sequences flanking different genes. Once bound to DNA directly or as part of a complex, they can promote or inhibit RNA polymerase recruitment, thereby acting as activators or repressors, respectively. Alternatively, transcription factors can act to recruit coactivators and corepressors or to catalyze histone acetylation and deacetylation. Transcription factors can function downstream of signaling cascades triggered by biological or environmental (ex. hypoxia, hyperthermia) stimuli to alter the expression of target genes. Ligand binding is necessary to activate some transcription factors as this can cause nuclear translocation and changes in the binding affinities for DNA and cofactors. During development, various stimuli can cause transcription factors to up- or down-regulate expression of specific genes at distinct time points to ensure proper development. Transcription factors can function as oncogenes or tumor suppressors and have thus been linked to various cancers. Accordingly, some therapeutic approaches in cancer therapy involve targeting transcription factor families[1].

1. Darnell JE Jr. 2002. Transcription factors as targets for cancer therapy. Nat Rev Cancer. Oct;2(10):740-9.

Transcription Factor Antibodies Top 20 Showcase


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Transcription Factors are involved in transcriptional regulation in the form of up regulation or down regulation acting as either repressors or activators of transcription. We have manufactured more than 3000 antibody products covering almost every known human and mouse transcription factors.

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  1. Mouse Thymus
    NOBOX Antibody - middle region (ARP90976_P050)
    Catalog #: ARP90976_P050
    Protein Name: homeobox protein NOBOX
    Alias: OG2, Og2x
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  2. Mouse Spleen
    MTERF Antibody - middle region (ARP90930_P050)
    Catalog #: ARP90930_P050
    Protein Name: transcription termination factor 1a, mitochondrial
    Alias: Mterf, Mterf1, mTERF1b, 4931431L11Rik, 9230106K09Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  3. Mouse Brain
    HOXB7 Antibody - middlel region (ARP89758_P050)
    Catalog #: ARP89758_P050
    Protein Name: homeobox protein Hox-B7
    Alias: Hox-2.3, AI325018
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  4. Mouse Testis
    HOXB1 Antibody - middlel region (ARP89658_P050)
    Catalog #: ARP89658_P050
    Protein Name: homeobox protein Hox-B1
    Alias: Hox-2.9
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  5. Mouse Heart
    HOXC4 Antibody - middle region (ARP90572_P050)
    Catalog #: ARP90572_P050
    Protein Name: homeobox protein Hox-C4
    Alias: Hox-3.5
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  6. Human A549 Whole Cell
    IRF2 Antibody - middle region (ARP97876_P050)
    Catalog #: ARP97876_P050
    Protein Name: Interferon regulatory factor 2
    Alias: IRF-2
    Tested Species: Human
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  7. Human K562 Whole Cell
    GTF2H1 Antibody - middle region (ARP97725_P050)
    Catalog #: ARP97725_P050
    Protein Name: P62, BTF2, TFB1, TFIIH
    Alias: P62, BTF2, TFB1, TFIIH
    Tested Species: Human
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  8. Human RPMI 8226 Whole Cell
    SUPT16H Antibody - C-terminal region (ARP97492_P050)
    Catalog #: ARP97492_P050
    Protein Name: CDC68, SPT16, FACTP140, SPT16/CDC68
    Alias: CDC68, SPT16, FACTP140, SPT16/CDC68
    Tested Species: Human
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  9. Mouse Kidney
    PURA Antibody - middle region (ARP89317_P050)
    Catalog #: ARP89317_P050
    Protein Name: CAGER-1, ssCRE-BP, Pur-alpha
    Alias: CAGER-1, ssCRE-BP, Pur-alpha
    Tested Species: Mouse
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
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