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Transcription Factor

Transcription factors are proteins that regulate gene expression by binding to DNA via one or more DNA-binding domains. This binding is achieved via a combination of electrostatic and van der waals forces and can occur at many closely-related sequences flanking different genes. Once bound to DNA directly or as part of a complex, they can promote or inhibit RNA polymerase recruitment, thereby acting as activators or repressors, respectively. Alternatively, transcription factors can act to recruit coactivators and corepressors or to catalyze histone acetylation and deacetylation. Transcription factors can function downstream of signaling cascades triggered by biological or environmental (ex. hypoxia, hyperthermia) stimuli to alter the expression of target genes. Ligand binding is necessary to activate some transcription factors as this can cause nuclear translocation and changes in the binding affinities for DNA and cofactors. During development, various stimuli can cause transcription factors to up- or down-regulate expression of specific genes at distinct time points to ensure proper development. Transcription factors can function as oncogenes or tumor suppressors and have thus been linked to various cancers. Accordingly, some therapeutic approaches in cancer therapy involve targeting transcription factor families[1].

1. Darnell JE Jr. 2002. Transcription factors as targets for cancer therapy. Nat Rev Cancer. Oct;2(10):740-9.

Transcription Factor Antibodies Top 20 Showcase


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Transcription Factors are involved in transcriptional regulation in the form of up regulation or down regulation acting as either repressors or activators of transcription. We have manufactured more than 3000 antibody products covering almost every known human and mouse transcription factors.

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    ACHA6 Antibody (ARP73928_P050) in Human Fetal Kidney using Western Blot

    CHRNA6 Antibody - middle region (ARP73928_P050)

    Protein Name:neuronal acetylcholine receptor subunit alpha-6
    Catalog #:ARP73928_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    DMBX1 Antibody (ARP32156_P050) in Human 786-0 Whole Cell using Western Blot

    DMBX1 Antibody - middle region (ARP32156_P050)

    Protein Name:Diencephalon/mesencephalon homeobox protein 1
    Catalog #:ARP32156_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    PHF21A antibody - middle region (ARP34557_P050) in Human Jurkat using Western Blot

    PHF21A Antibody - middle region (ARP34557_P050)

    Protein Name:PHD finger protein 21A
    Catalog #:ARP34557_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    MED16 Antibody - middle region (ARP57928_P050) in Human 293T using Western Blot

    MED16 Antibody - middle region (ARP57928_P050)

    Protein Name:Mediator of RNA polymerase II transcription subunit 16
    Catalog #:ARP57928_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    ARID3B antibody - N-terminal region (ARP38797_P050) in Human ACHN using Western Blot

    ARID3B Antibody - N-terminal region (ARP38797_P050)

    Protein Name:AT-rich interactive domain-containing protein 3B
    Catalog #:ARP38797_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    ZN480 Antibody (ARP75853_P050) in Human Stomach Tumor using Western Blot

    ZNF480 Antibody - N-terminal region (ARP75853_P050)

    Protein Name:zinc finger protein 480
    Catalog #:ARP75853_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00

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