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RNA Binding Proteins

RNA-binding proteins (RBPs) are critical regulators of RNA metabolism. RBPs play a role in translational regulation and can influence the stability, function, transport, and cellular localization of RNA transcripts[1]. RBPs can bind to both coding and non-coding untranslated RNA via single- or double-stranded RNA-binding motifs to form ribonucleic protein complexes (RNPs). The specific RBP binding domain and the individual RNA sequence determine RBP binding specificity. Single RBPs routinely bind several mRNA transcripts of proteins of similar function. In addition to transcriptional regulation, RNP function can also be attenuated by intra- or extracellular signals via post-translational modifications that affect their ability to sequester specific RNA sequences. More than 500 unique RBPs have been identified in the human genome.

In addition to binding RNA sequences, recent research has identified other roles for RBPs, including acting as substrates for kinases in DNA damage responses and influencing cell attachments through association with focal adhesion kinases[2].

Several human diseases have been linked to genetic defects in RNA-binding proteins. For instance, loss of function of specific RBPs have been associated with spinal muscular atrophy and Fragile X Syndrome. Conversely, RBP gain of function has been associated with myotonic dystrophy and oculopharyngeal muscular dystrophy. Based on the potential influence of RBPs on cell cycle, growth, and proliferation, they are implicated in several different malignancies, including breast and prostate cancers[3].

1. Glisovic et al. 2008. FEBS Lett. RNA-binding proteins and post-transcriptional gene regulation. 582(14):1977-86.
2. Lukong et al. 2008. Trends Genet. RNA-binding proteins in human genetic disease. 24(8):416-25.
3. Keene. 2007. Nature Reviews Genetics. RNA regulons: coordination of post-transcriptional events. 8, 533-543.


Proteins that bind to RNA molecules such as ribonucleic proteins and other proteins whose function is to bind specifically to RNA. These proteins may regulate the translation of RNA, and post-transcriptional events, such as RNA splicing, editing. We have manufactured antibody products for ~700 of these kinds of protein.

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    E2F1 Antibody (OAAB01868) in phospho-peptide and non-phospho-peptide using Dot Blot.

    E2F1 Antibody (Phospho-Ser332) (OAAB01868)

    Protein Name:Transcription factor E2F1
    Catalog #:OAAB01868
    Type: pAb
    Reacts with: Human
    Application: DB, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    IL17A Antibody (OASA07869)

    IL17A Antibody (OASA07869)

    Protein Name:Interleukin-17A
    Catalog #:OASA07869
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1 mg
    Price (USD): $609.00
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    PRKCA antibody - N-terminal region (OAAB05169) in NIH-3T3 using Western Blot

    PRKCA Antibody - N-terminal region (OAAB05169)

    Protein Name:Protein kinase C alpha type
    Catalog #:OAAB05169
    Type: pAb
    Reacts with: Human, Mouse
    Application: WB, IHC, FC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    ROA1 Antibody (ARP76272_P050) in Human Fetal Lung using Western Blot

    HNRNPA1 Antibody - C-terminal region (ARP76272_P050)

    Protein Name:heterogeneous nuclear ribonucleoprotein A1
    Catalog #:ARP76272_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    PBX1 Antibody (OAEB01717) in K562cells using Western Blot

    PBX1 Antibody (OAEB01717)

    Protein Name:Pre-B-cell leukemia transcription factor 1
    Catalog #:OAEB01717
    Type: pAb
    Reacts with: Cow, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    RAPTOR Blocking Peptide (OESA09476)

    RAPTOR Blocking Peptide (OESA09476)

    Protein Name:
    Catalog #:OESA09476
    Type: Peptide
    Reacts with: Human
    Application:
    Product Size: 50ug
    Price (USD): $245.00
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    Goat Anti-PRDM16 / MEL1 Antibody (OAEB00372)

    Goat Anti-PRDM16 / MEL1 Antibody (OAEB00372)

    Protein Name:PR domain zinc finger protein 16
    Catalog #:OAEB00372
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Rabbit
    Application: P-ELISA, CHIP
    Product Size: 100 ug
    Price (USD): $349.00
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    SART1 Antibody (OAEB02010) in Helacells using Western Blot

    SART1 Antibody (OAEB02010)

    Protein Name:U4/U6.U5 tri-snRNP-associated protein 1
    Catalog #:OAEB02010
    Type: pAb
    Reacts with: Cow, Horse, Human, Pig, Rabbit
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    CUX1 Antibody (C-term) (OAAB03295) in MCF-7 using Western Blot

    CUX1 Antibody - C-terminal region (OAAB03295)

    Protein Name:Homeobox protein cut-like 1
    Catalog #:OAAB03295
    Type: pAb
    Reacts with: Human
    Application: WB, IHC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    BMP2 Antibody (OASA07470)

    BMP2 Antibody (OASA07470)

    Protein Name:Bone morphogenetic protein 2
    Catalog #:OASA07470
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 50 ug
    Price (USD): $395.00
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    IL1A Antibody (OAAB03968) in 293 using Western Blot

    IL1A Antibody (OAAB03968)

    Protein Name:Interleukin-1 alpha
    Catalog #:OAAB03968
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 400ul
    Price (USD): $390.00
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    AKT1 Antibody (OAAB02110) in phospho-peptide and non-phospho-peptide using Dot Blot.

    AKT1 Antibody (Phospho-Thr308) (OAAB02110)

    Protein Name:RAC-alpha serine/threonine-protein kinase
    Catalog #:OAAB02110
    Type: pAb
    Reacts with: Human
    Application: DB, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    CCAR1 Antibody (OAEB01259) in Rat Skeletal Musclecells using Western Blot

    CCAR1 Antibody (OAEB01259)

    Protein Name:Cell division cycle and apoptosis regulator protein 1
    Catalog #:OAEB01259
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    APLP1 Protein Lysate (APL10377)

    APLP1 Protein Lysate (APL10377)

    Protein Name:Amyloid-like protein 1
    Catalog #:APL10377
    Type: Lysate
    Reacts with:
    Application:
    Product Size: 200ug
    Price (USD): $219.00
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    PIAS2 cDNA (ANA10996)

    PIAS2 cDNA (ANA10996)

    Protein Name:E3 SUMO-protein ligase PIAS2
    Catalog #:ANA10996
    Type: DNA
    Reacts with:
    Application:
    Product Size: 1ug
    Price (USD): $189.00

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