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RNA Binding Proteins

RNA-binding proteins (RBPs) are critical regulators of RNA metabolism. RBPs play a role in translational regulation and can influence the stability, function, transport, and cellular localization of RNA transcripts[1]. RBPs can bind to both coding and non-coding untranslated RNA via single- or double-stranded RNA-binding motifs to form ribonucleic protein complexes (RNPs). The specific RBP binding domain and the individual RNA sequence determine RBP binding specificity. Single RBPs routinely bind several mRNA transcripts of proteins of similar function. In addition to transcriptional regulation, RNP function can also be attenuated by intra- or extracellular signals via post-translational modifications that affect their ability to sequester specific RNA sequences. More than 500 unique RBPs have been identified in the human genome.

In addition to binding RNA sequences, recent research has identified other roles for RBPs, including acting as substrates for kinases in DNA damage responses and influencing cell attachments through association with focal adhesion kinases[2].

Several human diseases have been linked to genetic defects in RNA-binding proteins. For instance, loss of function of specific RBPs have been associated with spinal muscular atrophy and Fragile X Syndrome. Conversely, RBP gain of function has been associated with myotonic dystrophy and oculopharyngeal muscular dystrophy. Based on the potential influence of RBPs on cell cycle, growth, and proliferation, they are implicated in several different malignancies, including breast and prostate cancers[3].

1. Glisovic et al. 2008. FEBS Lett. RNA-binding proteins and post-transcriptional gene regulation. 582(14):1977-86.
2. Lukong et al. 2008. Trends Genet. RNA-binding proteins in human genetic disease. 24(8):416-25.
3. Keene. 2007. Nature Reviews Genetics. RNA regulons: coordination of post-transcriptional events. 8, 533-543.


Proteins that bind to RNA molecules such as ribonucleic proteins and other proteins whose function is to bind specifically to RNA. These proteins may regulate the translation of RNA, and post-transcriptional events, such as RNA splicing, editing. We have manufactured antibody products for ~700 of these kinds of protein.

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    Rab5 Antibody (C-term) (OAAB04097) in HL-60 using Western Blot

    RAB5A Antibody - C-terminal region (OAAB04097)

    Protein Name:Ras-related protein Rab-5A
    Catalog #:OAAB04097
    Type: pAb
    Reacts with: Human
    Application: WB, IHC, IF, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    Goat Anti-PP2A / PPP2R1A Antibody (OAEB02257) in Human Lymph Nodecells using Western Blot

    Goat Anti-PP2A / PPP2R1A Antibody (OAEB02257)

    Protein Name:Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
    Catalog #:OAEB02257
    Type: pAb
    Reacts with: Cow, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    HNF4G antibody - C-terminal region (ARP45616_P050) in Human MCF-7 using Western Blot

    HNF4G Antibody - C-terminal region (ARP45616_P050)

    Protein Name:Hepatocyte nuclear factor 4-gamma
    Catalog #:ARP45616_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    SENP2 cDNA (ANA11309)

    SENP2 cDNA (ANA11309)

    Protein Name:
    Catalog #:ANA11309
    Type: DNA
    Reacts with:
    Application:
    Product Size: 1ug
    Price (USD): $189.00
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    KHDRBS1 Antibody - C-terminal region (ARP87492_P050) in Human HepG2 Whole Cell using Western Blot

    KHDRBS1 Antibody - C-terminal region (ARP87492_P050)

    Protein Name:KH domain-containing, RNA-binding, signal transduction-associated protein 1
    Catalog #:ARP87492_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    CCAR1 Antibody (OAEB01259) in Rat Skeletal Musclecells using Western Blot

    CCAR1 Antibody (OAEB01259)

    Protein Name:Cell division cycle and apoptosis regulator protein 1
    Catalog #:OAEB01259
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    FEN1 antibody - C-terminal region (ARP46097_T100) in Human HepG2 using Western Blot

    FEN1 Antibody - C-terminal region (ARP46097_T100)

    Protein Name:Flap endonuclease 1
    Catalog #:ARP46097_T100
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    CDC5L antibody - center region (OAAB05545) in MCF-7 using Western Blot

    CDC5L Antibody - middle region (OAAB05545)

    Protein Name:Cell division cycle 5-like protein
    Catalog #:OAAB05545
    Type: pAb
    Reacts with: Human
    Application: WB, IHC, FC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    CRK Protein Lysate (APL10281)

    CRK Protein Lysate (APL10281)

    Protein Name:Adapter molecule crk
    Catalog #:APL10281
    Type: Lysate
    Reacts with:
    Application:
    Product Size: 200ug
    Price (USD): $219.00
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    SNRPA antibody - N-terminal region (ARP40530_P050) in Human HeLa using Western Blot

    SNRPA Antibody - N-terminal region (ARP40530_P050)

    Protein Name:U1 small nuclear ribonucleoprotein A
    Catalog #:ARP40530_P050
    Type: pAb
    Reacts with: Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    SARS2 antibody - center region (OAAB04888) in Hela using Western Blot

    SARS2 Antibody - middle region (OAAB04888)

    Protein Name:Serine--tRNA ligase, mitochondrial
    Catalog #:OAAB04888
    Type: pAb
    Reacts with: Human
    Application: WB, IHC, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    TNKS1BP1 Antibody (OAEB00709)

    TNKS1BP1 Antibody (OAEB00709)

    Protein Name:182 kDa tankyrase-1-binding protein
    Catalog #:OAEB00709
    Type: pAb
    Reacts with: Human, Rabbit
    Application: ELISA
    Product Size: 100 ug
    Price (USD): $349.00

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