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RNA Binding Proteins

RNA-binding proteins (RBPs) are critical regulators of RNA metabolism. RBPs play a role in translational regulation and can influence the stability, function, transport, and cellular localization of RNA transcripts[1]. RBPs can bind to both coding and non-coding untranslated RNA via single- or double-stranded RNA-binding motifs to form ribonucleic protein complexes (RNPs). The specific RBP binding domain and the individual RNA sequence determine RBP binding specificity. Single RBPs routinely bind several mRNA transcripts of proteins of similar function. In addition to transcriptional regulation, RNP function can also be attenuated by intra- or extracellular signals via post-translational modifications that affect their ability to sequester specific RNA sequences. More than 500 unique RBPs have been identified in the human genome.

In addition to binding RNA sequences, recent research has identified other roles for RBPs, including acting as substrates for kinases in DNA damage responses and influencing cell attachments through association with focal adhesion kinases[2].

Several human diseases have been linked to genetic defects in RNA-binding proteins. For instance, loss of function of specific RBPs have been associated with spinal muscular atrophy and Fragile X Syndrome. Conversely, RBP gain of function has been associated with myotonic dystrophy and oculopharyngeal muscular dystrophy. Based on the potential influence of RBPs on cell cycle, growth, and proliferation, they are implicated in several different malignancies, including breast and prostate cancers[3].

1. Glisovic et al. 2008. FEBS Lett. RNA-binding proteins and post-transcriptional gene regulation. 582(14):1977-86.
2. Lukong et al. 2008. Trends Genet. RNA-binding proteins in human genetic disease. 24(8):416-25.
3. Keene. 2007. Nature Reviews Genetics. RNA regulons: coordination of post-transcriptional events. 8, 533-543.


Proteins that bind to RNA molecules such as ribonucleic proteins and other proteins whose function is to bind specifically to RNA. These proteins may regulate the translation of RNA, and post-transcriptional events, such as RNA splicing, editing. We have manufactured antibody products for ~700 of these kinds of protein.

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    CCDC111 cDNA (ANA11573)

    CCDC111 cDNA (ANA11573)

    Protein Name:
    Catalog #:ANA11573
    Type: DNA
    Reacts with:
    Application:
    Product Size: 1ug
    Price (USD): $189.00
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    CDK9 Antibody (OASA07138)

    CDK9 Antibody (OASA07138)

    Protein Name:Cyclin-dependent kinase 9
    Catalog #:OASA07138
    Type: pAb
    Reacts with: Human
    Application: IHC-AFF, IP, IHC-FFPE, WB
    Product Size: 0.1 ml
    Price (USD): $969.00
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    PSMB10 Antibody (OAEB02200) in Human Lungcells using Western Blot

    PSMB10 Antibody (OAEB02200)

    Protein Name:Proteasome subunit beta type-10
    Catalog #:OAEB02200
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ug
    Price (USD): $299.00
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    CCL2 Antibody (OASA03110)

    CCL2 Antibody (OASA03110)

    Protein Name:C-C motif chemokine 2
    Catalog #:OASA03110
    Type: mAb
    Reacts with: Human
    Application: WB
    Product Size: 0.5 mg
    Price (USD): $659.00
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    SRCAP Antibody (OAEB00810)

    SRCAP Antibody (OAEB00810)

    Protein Name:Helicase SRCAP
    Catalog #:OAEB00810
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application:
    Product Size: 100 ug
    Price (USD): $299.00
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    POR Antibody (OAEB01434) in Rat Livercells using Western Blot

    POR Antibody (OAEB01434)

    Protein Name:NADPH--cytochrome P450 reductase PIRNR PIRNR000208
    Catalog #:OAEB01434
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse
    Application: WB
    Product Size: 100 ug
    Price (USD): $299.00
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    CBX6 Antibody (OAEB00654)

    CBX6 Antibody (OAEB00654)

    Protein Name:Chromobox protein homolog 6
    Catalog #:OAEB00654
    Type: pAb
    Reacts with: Cow, Dog, Human, Mouse, Rat
    Application:
    Product Size: 100 ug
    Price (USD): $229.00
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    EIF3A Antibody - C-terminal region (ARP84537_P050) in Human HT1080 Whole Cell using Western Blot

    EIF3A Antibody - C-terminal region (ARP84537_P050)

    Protein Name:eukaryotic translation initiation factor 3 subunit A
    Catalog #:ARP84537_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    CD2BP2 antibody - N-terminal region (OAEB01750) in Human Thymuscells using Western Blot

    CD2BP2 Antibody - N-terminal region (OAEB01750)

    Protein Name:CD2 antigen cytoplasmic tail-binding protein 2
    Catalog #:OAEB01750
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Mouse, Rat
    Application: WB
    Product Size: 100 ug
    Price (USD): $299.00
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    AKT1 Antibody (OAAB02110) in phospho-peptide and non-phospho-peptide using Dot Blot.

    AKT1 Antibody (Phospho-Thr308) (OAAB02110)

    Protein Name:RAC-alpha serine/threonine-protein kinase
    Catalog #:OAAB02110
    Type: pAb
    Reacts with: Human
    Application: DB
    Product Size: 400ul
    Price (USD): $329.00
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    STAT6 Blocking Peptide (OESA09493)

    STAT6 Blocking Peptide (OESA09493)

    Protein Name:
    Catalog #:OESA09493
    Type: Peptide
    Reacts with: Human
    Application:
    Product Size: 50ug
    Price (USD): $260.00
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    SCYE1 antibody - middle region (ARP40552_P050) in Human HEK293T using Western Blot

    SCYE1 Antibody - middle region (ARP40552_P050)

    Protein Name:Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
    Catalog #:ARP40552_P050
    Type: pAb
    Reacts with: Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    CALR antibody - center region (OAAB04011) in Ramos, Jurkat, HepG2, NIH-3T3 using Western Blot

    CALR Antibody - middle region (OAAB04011)

    Protein Name:Calreticulin
    Catalog #:OAAB04011
    Type: pAb
    Reacts with: Human, Mouse
    Application: WB, IHC
    Product Size: 200ul
    Price (USD): $329.00
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    STRBP antibody - middle region (ARP40914_P050) in Transfected 293T using Western Blot

    STRBP Antibody - middle region (ARP40914_P050)

    Protein Name:Spermatid perinuclear RNA-binding protein
    Catalog #:ARP40914_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    RPN1 antibody - N-terminal region (ARP40436_P050) in HeLa , CHO-K1, rouch canine microsomes using Western Blot

    RPN1 Antibody - N-terminal region (ARP40436_P050)

    Protein Name:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
    Catalog #:ARP40436_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Yeast, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $229.00
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    FASTK cDNA (ANA11052)

    FASTK cDNA (ANA11052)

    Protein Name:Fas-activated serine/threonine kinase
    Catalog #:ANA11052
    Type: DNA
    Reacts with:
    Application:
    Product Size: 1ug
    Price (USD): $189.00
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    TGF Beta 3 Protein (OPMA04633)

    TGF Beta 3 Protein (OPMA04633)

    Protein Name:Transforming growth factor beta-3
    Catalog #:OPMA04633
    Type: Protein
    Reacts with: Human
    Application:
    Product Size: 0.1 mg
    Price (USD): $2,819.00
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    C22orf28 cDNA (ANA11111)

    C22orf28 cDNA (ANA11111)

    Protein Name:tRNA-splicing ligase RtcB homolog
    Catalog #:ANA11111
    Type: DNA
    Reacts with:
    Application:
    Product Size: 1ug
    Price (USD): $189.00

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