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RNA Binding Proteins

RNA-binding proteins (RBPs) are critical regulators of RNA metabolism. RBPs play a role in translational regulation and can influence the stability, function, transport, and cellular localization of RNA transcripts[1]. RBPs can bind to both coding and non-coding untranslated RNA via single- or double-stranded RNA-binding motifs to form ribonucleic protein complexes (RNPs). The specific RBP binding domain and the individual RNA sequence determine RBP binding specificity. Single RBPs routinely bind several mRNA transcripts of proteins of similar function. In addition to transcriptional regulation, RNP function can also be attenuated by intra- or extracellular signals via post-translational modifications that affect their ability to sequester specific RNA sequences. More than 500 unique RBPs have been identified in the human genome.

In addition to binding RNA sequences, recent research has identified other roles for RBPs, including acting as substrates for kinases in DNA damage responses and influencing cell attachments through association with focal adhesion kinases[2].

Several human diseases have been linked to genetic defects in RNA-binding proteins. For instance, loss of function of specific RBPs have been associated with spinal muscular atrophy and Fragile X Syndrome. Conversely, RBP gain of function has been associated with myotonic dystrophy and oculopharyngeal muscular dystrophy. Based on the potential influence of RBPs on cell cycle, growth, and proliferation, they are implicated in several different malignancies, including breast and prostate cancers[3].

1. Glisovic et al. 2008. FEBS Lett. RNA-binding proteins and post-transcriptional gene regulation. 582(14):1977-86.
2. Lukong et al. 2008. Trends Genet. RNA-binding proteins in human genetic disease. 24(8):416-25.
3. Keene. 2007. Nature Reviews Genetics. RNA regulons: coordination of post-transcriptional events. 8, 533-543.


Proteins that bind to RNA molecules such as ribonucleic proteins and other proteins whose function is to bind specifically to RNA. These proteins may regulate the translation of RNA, and post-transcriptional events, such as RNA splicing, editing. We have manufactured antibody products for ~700 of these kinds of protein.

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    Human MCP-1/MCAF Protein (OPSA10966)

    Human MCP-1/MCAF Protein (OPSA10966)

    Protein Name:C-C motif chemokine 2
    Catalog #:OPSA10966
    Type: Protein
    Reacts with: Human
    Application:
    Product Size: 20 ug
    Price (USD): $459.00
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    THRB Antibody (OAEB00386) in Zebrafish adult heart tissue using Western Blot

    THRB Antibody (OAEB00386)

    Protein Name:Thyroid hormone receptor beta
    Catalog #:OAEB00386
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ug
    Price (USD): $349.00
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    APOBEC2 antibody - middle region (ARP40682_P050) in COLO205 using Western Blot

    APOBEC2 Antibody - middle region (ARP40682_P050)

    Protein Name:Probable C->U-editing enzyme APOBEC-2
    Catalog #:ARP40682_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    LPPRC Antibody (ARP41093_P050) in Human 293T Whole Cell using Western Blot

    LRPPRC Antibody - N-terminal region (ARP41093_P050)

    Protein Name:leucine-rich PPR motif-containing protein, mitochondrial
    Catalog #:ARP41093_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    NXF1 cDNA (ANA11383)

    NXF1 cDNA (ANA11383)

    Protein Name:
    Catalog #:ANA11383
    Type: DNA
    Reacts with:
    Application:
    Product Size: 1ug
    Price (USD): $189.00
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    STAU1 cDNA (ANA10909)

    STAU1 cDNA (ANA10909)

    Protein Name:Double-stranded RNA-binding protein Staufen homolog 1
    Catalog #:ANA10909
    Type: DNA
    Reacts with:
    Application:
    Product Size: 1ug
    Price (USD): $189.00
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    ALF antibody - N-terminal region (ARP32837_P050) in Human Jurkat using Western Blot

    ALF Antibody - N-terminal region (ARP32837_P050)

    Protein Name:TFIIA-alpha and beta-like factor
    Catalog #:ARP32837_P050
    Type: pAb
    Reacts with: Cow, Dog, Guinea Pig, Horse, Human, Rabbit, Rat
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    UBE2I Antibody (OAEB02456) in Human Kidneycells using Western Blot

    UBE2I Antibody (OAEB02456)

    Protein Name:SUMO-conjugating enzyme UBC9
    Catalog #:OAEB02456
    Type: pAb
    Reacts with: Cow, Human, Mouse
    Application: WB, IHC
    Product Size: 100 ug
    Price (USD): $349.00
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    AHR Antibody (OASA07386)

    AHR Antibody (OASA07386)

    Protein Name:Aryl hydrocarbon receptor
    Catalog #:OASA07386
    Type: pAb
    Reacts with: Human
    Application: IHC-FFPE
    Product Size: 50 ug
    Price (USD): $920.00
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    NRL cDNA (ANA10379)

    NRL cDNA (ANA10379)

    Protein Name:Neural retina-specific leucine zipper protein
    Catalog #:ANA10379
    Type: DNA
    Reacts with:
    Application:
    Product Size: 1ug
    Price (USD): $189.00
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    PIGZ antibody - N-terminal region (ARP41020_P050) in Human HeLa using Western Blot

    PIGZ Antibody - N-terminal region (ARP41020_P050)

    Protein Name:GPI mannosyltransferase 4
    Catalog #:ARP41020_P050
    Type: pAb
    Reacts with: Cow, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    DDX20 Antibody - middle region (ARP88277_P050) in Human PANC1 Whole Cell using Western Blot

    DDX20 Antibody - middle region (ARP88277_P050)

    Protein Name:Probable ATP-dependent RNA helicase DDX20
    Catalog #:ARP88277_P050
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 100 ul
    Price (USD): $289.00
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    USP2 Antibody (OASA08264)

    USP2 Antibody (OASA08264)

    Protein Name:Ubiquitin carboxyl-terminal hydrolase 2
    Catalog #:OASA08264
    Type: pAb
    Reacts with: Human
    Application: IHC-FFPE
    Product Size: 50 ug
    Price (USD): $770.00
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    MYCN antibody - C-terminal region (OAAB04416) in CEM using Western Blot

    MYCN Antibody - C-terminal region (OAAB04416)

    Protein Name:N-myc proto-oncogene protein
    Catalog #:OAAB04416
    Type: pAb
    Reacts with: Human
    Application: WB, ELISA
    Product Size: 400ul
    Price (USD): $390.00
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    PSMB1 antibody - C-terminal region (OAAB05451) in mouse NIH-3T3 and mouse bladder using Western Blot

    PSMB1 Antibody - C-terminal region (OAAB05451)

    Protein Name:Proteasome subunit beta type-1
    Catalog #:OAAB05451
    Type: pAb
    Reacts with: Human, Mouse
    Application: WB, IHC, ELISA
    Product Size: 400ul
    Price (USD): $390.00

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