RNA Binding Proteins

RNA-binding proteins (RBPs) are critical regulators of RNA metabolism. RBPs play a role in translational regulation and can influence the stability, function, transport, and cellular localization of RNA transcripts[1]. RBPs can bind to both coding and non-coding untranslated RNA via single- or double-stranded RNA-binding motifs to form ribonucleic protein complexes (RNPs). The specific RBP binding domain and the individual RNA sequence determine RBP binding specificity. Single RBPs routinely bind several mRNA transcripts of proteins of similar function. In addition to transcriptional regulation, RNP function can also be attenuated by intra- or extracellular signals via post-translational modifications that affect their ability to sequester specific RNA sequences. More than 500 unique RBPs have been identified in the human genome.

In addition to binding RNA sequences, recent research has identified other roles for RBPs, including acting as substrates for kinases in DNA damage responses and influencing cell attachments through association with focal adhesion kinases[2].

Several human diseases have been linked to genetic defects in RNA-binding proteins. For instance, loss of function of specific RBPs have been associated with spinal muscular atrophy and Fragile X Syndrome. Conversely, RBP gain of function has been associated with myotonic dystrophy and oculopharyngeal muscular dystrophy. Based on the potential influence of RBPs on cell cycle, growth, and proliferation, they are implicated in several different malignancies, including breast and prostate cancers[3].

1. Glisovic et al. 2008. FEBS Lett. RNA-binding proteins and post-transcriptional gene regulation. 582(14):1977-86.
2. Lukong et al. 2008. Trends Genet. RNA-binding proteins in human genetic disease. 24(8):416-25.
3. Keene. 2007. Nature Reviews Genetics. RNA regulons: coordination of post-transcriptional events. 8, 533-543.


Proteins that bind to RNA molecules such as ribonucleic proteins and other proteins whose function is to bind specifically to RNA. These proteins may regulate the translation of RNA, and post-transcriptional events, such as RNA splicing, editing. We have manufactured antibody products for ~700 of these kinds of protein.

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  1. Mouse Thymus
    RBMX Antibody - middle region (ARP90778_P050)
    Catalog #: ARP90778_P050
    Protein Name: RNA binding motif protein, X-linked-like-1
    Alias: Rbmx, Hnrpg, Rbmxrt
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  2. Mouse Lung
    RNPS1 Antibody - middle region (ARP90731_P050)
    Catalog #: ARP90731_P050
    Protein Name: RNA-binding protein with serine-rich domain 1
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  3. Mouse Thymus
    DDX6 Antibody - N-terminal region (ARP89848_P050)
    Catalog #: ARP89848_P050
    Protein Name: probable ATP-dependent RNA helicase DDX6
    Alias: p54, rck, HLR2, mRCK/P54, 1110001P04Rik, E230023J21Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  4. Mouse Pancreas
    EIF4G2 Antibody - N-terminal region (ARP90937_P050)
    Catalog #: ARP90937_P050
    Protein Name: eukaryotic translation initiation factor 4 gamma 2
    Alias: p97, Nat1, DAP-5, Natm1, E130105L11Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  5. Mouse Brain
    IGF2BP3 Antibody - middle region (ARP90710_P050)
    Catalog #: ARP90710_P050
    Protein Name: insulin-like growth factor 2 mRNA-binding protein 3
    Alias: IMP3, IMP-3, Koc13, mimp3, Neilsen, AA522010, AL022933, AU045931, 2610101N11Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  6. Mouse Pancreas
    RBFOX1 Antibody - middle region (ARP90699_P050)
    Catalog #: ARP90699_P050
    Protein Name: RNA binding protein fox-1 homolog 1
    Alias: A2bp, A2bp1, fox-1, Hrnbp1
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  7. Mouse Pancreas
    TUFM Antibody - middle region (ARP90950_P050)
    Catalog #: ARP90950_P050
    Protein Name: elongation factor Tu, mitochondrial
    Alias: EFTU, C76308, C76389, EF-TuMT, 2300002G02Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  8. Mouse Brain
    NOVA1 Antibody - N-terminal region (ARP90851_P050)
    Catalog #: ARP90851_P050
    Protein Name: RNA-binding protein Nova-1
    Alias: Nova-1, G630039L02, 9430099M15Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  9. Mouse Lung
    ROD1 Antibody - middle region (ARP90536_P050)
    Catalog #: ARP90536_P050
    Protein Name: polypyrimidine tract-binding protein 3
    Alias: Rod1, C86549, AA407443, AI462022, AW107884, 5830471K22Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
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