Ion Channel

Ion channels are a class of membrane-bound proteins that are present on the surface of all cells as well as on intracellular organelles. Ion channels typically function by creating and maintaining an ion gradient across either cellular or organelle membranes. These channels, comprised of a variety of different protein subunits, contain a pore that can be as narrow as a single atom, allowing for precise control of ion passage.

Ion channels play a critical role in the proper functioning of the human nervous system. Voltage-gated ion channels are present on all neurons and it is the voltage gradient created and maintained by these channels that permits signal propagation; a change in the voltage across the membrane can cause the channel to open or close.

Ion channels, such as those that are present at neuronal synapses, can also be ligand-gated in which the binding of a specific ligand will result in a conformational change in the ion channel resulting in pore opening. In addition to voltage- and ligand-activated ion channels, ion channels can also be activated by heat, temperature, or mechanical stress.

Ion channels have a variety of biological functions, including roles in neuronal signal transmission, muscle contraction, T-cell activation, and insulin release from beta cells. Dysfunctional ion channel activity is the basis of many human diseases. For instance, cystic fibrosis is a result of a genetic mutation in the CFTR gene, which encodes a protein component of a chloride ion channel[1]. Specific natural or synthetic toxins can also affect the functional ability of ion channels; the puffer fish produces tetrodotoxin (TTX), which inhibits the function of sodium channels and can cause respiratory paralysis and death.

1. Rogan, et al. 2011. Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment. Chest. 139(6):1480-90.


Ion channels are gated, ion-selective glycoproteins that traverse membranes. The stimulus for channel gating can be a membrane potential, drug, transmitter, cytoplasmic messenger, or a mechanical deformation. We have manufactured products for ~200 human ion channel proteins.

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  1. Human HepG2 Whole Cell
    NUP133 Antibody - middle region (ARP75678_P050)
    Catalog #: ARP75678_P050
    Protein Name: Nuclear pore complex protein Nup133
    Alias: GAMOS8, NPHS18, hNUP133
    Predicted Species: Human
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  2. Mouse Spleen
    CHRNB3 Antibody - middle region (ARP90358_P050)
    Catalog #: ARP90358_P050
    Protein Name: neuronal acetylcholine receptor subunit beta-3
    Alias: Acrb3, 5730417K16Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  3. Mouse Liver
    KCNN2 Antibody - middle region (ARP91047_P050)
    Catalog #: ARP91047_P050
    Protein Name: small conductance calcium-activated potassium channel protein 2
    Alias: bc, SK2, fri, SKCA2, KCa2.2
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  4. Mouse Brain
    DPP6 Antibody - middle region (ARP90432_P050)
    Catalog #: ARP90432_P050
    Protein Name: dipeptidyl aminopeptidase-like protein 6
    Alias: Rw, Dpp-6, Peplb, D5Buc3, D5Buc4, D5Buc5, DPP VI, Gm1377, In(5)6H-p, B930011P16Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  5. Mouse Lung
    ATP5B Antibody - middlel region (ARP89713_P050)
    Catalog #: ARP89713_P050
    Protein Name: ATP synthase subunit beta, mitochondrial
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  6. Mouse MEF Whole Cell
    TMC1 Antibody - N-terminal region (ARP91109_P050)
    Catalog #: ARP91109_P050
    Protein Name: transmembrane channel-like protein 1
    Alias: dn, Bth, CWEA1, Beethoven, 4933416G09Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  7. Mouse SP2/0 Whole Cell
    SGK3 Antibody - N-terminal region (ARP90569_P050)
    Catalog #: ARP90569_P050
    Protein Name: serine/threonine-protein kinase Sgk3
    Alias: fy, fz, Cisk, 2510015P22Rik, A330005P07Rik
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  8. Mouse Thymus
    CLCN1 Antibody - C-terminal region (ARP90543_P050)
    Catalog #: ARP90543_P050
    Protein Name: chloride channel protein 1
    Alias: adr, mto, Clc1, Clc-1, SMCC1, nmf355, myotonia
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
  9. Mouse Liver
    KCNJ1 Antibody - middle region (ARP90520_P050)
    Catalog #: ARP90520_P050
    Protein Name: ATP-sensitive inward rectifier potassium channel 1
    Alias: ROMK, Romk2, Kir1.1
    Predicted Species: Mouse
    Application: WB
    Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
    Size: 100 ul
    Price:
    Special Price $229.00 Regular Price $289.00
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