PRNP Recombinant Protein (OPCD06415)

Catalog No: OPCD06415

PRNP Recombinant Protein (OPCD06415) using SDS-PAGE

PRNP Recombinant Protein (OPCD06415) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Lys23-Ser230
  Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. Cytoplasm. Nucle
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 90%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: PRNP
• Gene Full Name: prion protein
• Alias Symbols: alternative prion protein;AltPrP;ASCR;CD230;CD230 antigen;CJD;GSS;KURU;major prion protein;p27-30;prion-related protein;PRIP;PrP;PrP27-30;PrP33-35C;PrPc.
• NCBI Gene Id: 5621
• Protein Name: Major prion protein
• Description of Target: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
• Uniprot ID: P04156
• Protein Accession #: NP_000302.1
• Nucleotide Accession #: NM_000311.3
• Protein Size (# AA): Lys23~Ser230
• Molecular Weight: 26kDa