PRKX Antibody - C-terminal region (OAAB17329)

Catalog No: OAAB17329

Size:400ul

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with PRKX antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: IHC
• Additional Information: Precautions: PRKX Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation
  Cellular Location: Cytoplasm. Nucleus. Note=cAMP induces nuclear translocation
  Tissue Location: Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This PRKX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-343 amino acids from the C-terminal region of human PRKX.
• Predicted Homology Based on Immunogen Sequence: Human; Mouse
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: IHC-P: 1:10~50

Target Info

• Gene Symbol: PRKX
• Alias Symbols: PKX1
• NCBI Gene Id: 5613
• Protein Name: cAMP-dependent protein kinase catalytic subunit PRKX
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: P51817
• Protein Accession #: NP_005035.1
• Molecular Weight: 40896 Da